An interventional study of continous venovenous hemofiltraion in Intensive Care Unit, sponsored by First People's Hospital of Chenzhou. Status unknown at 1 site in China. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-09-10.
Sponsored by First People's Hospital of Chenzhou · Not applicable, Interventional, and Treatment
The plasma level of mtDNA in sepsis is affected by continous venovenous hemofiltation（CVVH）
Continous renal replacement therapy （CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .In clinical patients ，continous venovenous hemofoiltration （CVVH）is actually the method of chioce for CRRT in critically ill and hemodynamic instable patients .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index，increasing cardiac index and regulating immune dysfuntion .
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's enrollment of 20 is below the median of 105 across 896 interventional studies indexed under Sepsis.
Browse Sepsis studies →First People's Hospital of Chenzhou is the lead sponsor of 11 studies on the registry; 3 are open to participants now.
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Adult septic patients undergoing CRRT
Exclusion Criteria:
continuous venovenous hemofiltration. Continuous renal replacement therapy（CRRT）has become routine for patients with chronic renal failure ，AKI，fliud overload as well as oliguria in ICU .Continuous venovenous hemofiltration（CVVH）is the method of chioce for CRRT in critical ill .CVVH has significant beneficial effects on removing inflammatory cytokines ，improving oxygen index ，decreasing vasopressor requirements，increasing cardiac index and regulating immune dysfunction .
Procedure: continous venovenous hemofiltraion
CVVH
Change of mtDNA concentration in plasma
The specimens in the prefilter and postfilter blood as well as in the ultrafiltrate were obtained at the beginning of CRRT (T0) and 6 h (T6h), 12 h (T12h) after the setup of CVVH.
Time frame: befor,6hours, 12hours, after CVVH treatment
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First People's Hospital of Chenzhou