An interventional study of cognitive behavioral treatment of insomnia in Insomnia Chronic, sponsored by University of Pennsylvania. Completed at 1 site in United States. Open to participants aged 30 Years to 50 Years. Per ClinicalTrials.gov, last updated 2023-01-17.
Sponsored by University of Pennsylvania · Not applicable, Interventional, and Treatment
The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years. The purpose of this study is to examine whether treatment of insomnia with cognitive behavioral therapy (CBT-I) is associated with a decrease in dementia biomarkers found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia will undergo overnight polysomnography and CSF sampling in the morning. This will be followed by 8 weeks of treatment with CBT-I and then repeat CSF sampling.
2,172 studies on the registry are indexed under Dementia; 541 are open to participants now.
This study's enrollment of 9 is below the median of 83 across 1,629 interventional studies indexed under Dementia.
Browse Dementia studies →University of Pennsylvania is the lead sponsor of 1,635 studies on the registry; 239 are open to participants now.
Of its 154 completed or terminated interventional studies of FDA-regulated products, 104 (68%) have results posted.
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Exclusion Criteria:
Eight weeks of cognitive behavioral treatment of insomnia.
Behavioral: cognitive behavioral treatment of insomnia
A behavioral modification program consisting of 8 clinic sessions focused on sleep hygiene, stimulus control, sleep restriction, and cognitive restructuring.
CSF markers related to dementia
CSF levels of the proteins tau and beta amyloid
Time frame: 8 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Jan 2023. You cannot join it, but the record below documents what was studied.
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University of Pennsylvania