Reproducibility and Utility of OGTT in Acromegaly

• Acromegalic subjects

• Men or women, adults ≤ 85 years, with hypersecretion of GH proven by the following criteria:

  • High IGF-I compared to age and sex standards (Variety study, Chanson et al., 2016)
  • and basal GH concentrations > 0.4 μg / L (Katznelson, et al., 2014) and somatotropic pituitary adenoma operated on or planned to be operated on. It may be patients whose acromegaly has just been discovered and not yet treated (de novo patients) for whom a surgical treatment is envisaged within 6 months after inclusion or acromegalic patients already operated on a pituitary adenoma whose acromegaly is not controlled by surgery. A histological confirmation of a somatotropic pituitary adenoma will be obtained either before inclusion in the study (subjects already operated) or after inclusion ("de novo" subjects) in order to have a sufficient level of proof of the diagnosis of acromegaly, especially in the "intermediate" forms.
• Medically treated patients who decide to discontinue treatment (in order to reassess the progression of the disease, or at the time of a change), will be eligible after more than 3 months of discontinuation of the drug treatment.
• In women on estrogen / progestin contraception, this should be kept unchanged throughout the study. In the absence of estrogen / progestin contraception, exploration will be done in the follicular phase.

Non-acromegalic subjects:

• Men or women, adults ≤ 85 years
• Subjects defined by a concentration of IGF-I below 100% of the upper limit of normal, matched for sex and age (± 5 years) to acromegalic patients.
• Normal blood pressure measured by an electronic tensiometer validated after 5 min resting in supine position \<140/90 mmHg on 3 consecutive measurements
• Biological assessment (hematological and biochemical blood tests, urine analysis) within the limits of normal or clinically acceptable. Normal EKG.
• ECG 12 leads without particularity.
• Affiliation to a social security scheme
• At the women on estrogen-progestative contraception, this one should be kept unchanged throughout the study. In the absence of estrogen-progestative contraception,the exploration will be done in the follicular phase.
• Signed informed consent.

Exclusion Criteria:

For both groups:

• Pregnant or breastfeeding women
• Acute systemic diseases
• Pathologies likely to affect digestive absorption
• Taking prohibited treatments (see section 7.3)
• History of hypersensitivity to aspartame (edema of Quincke, Urticaria ..)
• Donation of blood in the 3 months preceding the study
• People in the exclusion period on the national file people suitable for research involving the human person
• Refusal or linguistic or psychic incapacity to sign informed consent
• Subject unable to submit to the constraints of the protocol (for example, non-cooperating, unable to return to follow-up visits and probably unable to finish the study)
• Major under guardianship
• Major under curatorship
• People with phenylketonuria
• Person with digestive intolerance to glucose /galactose, digestive labsorption syndrome of glucose / galactose.

For the group of acromegalic patients:

• acromegalic patients with diabetes mellitus treated with insulin
• Acromegalic patients under medical treatment of their acromegaly somatostatin analogues, pegvisomant), or patients in whom this treatment has been suspended for less than 3 months at the time of the selection.
• Acromegalic patients who have been treated with radiotherapy.

For the group of non-acromegalic subjects:

- Chronic systemic diseases likely to influence the secretion of GH like diabetes sweetness, severe obesity (BMI> 35 kg / m2), inadequate renal (creatinine clearance \<60 mL / min), disease hypothalamic-pituitary, epilepsy, antecedents Hepatocellular insufficiency and insufficiency cardiac, progressive cancer.