An observational study in Brain Infarction, sponsored by Centre Hospitalier Universitaire de Nīmes. Completed at 1 site in France. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2025-12-03.
Sponsored by Centre Hospitalier Universitaire de Nīmes · Observational
The investigator retrospectively analyzed consecutive young (\<60 years) cryptogenic stroke patients with Patient Foramen Ovale (PFO) recruited between January 2016 and May 2019 in our center, and compared these patients with sex- and age-matched controls with cryptogenic stroke without PFO. Analyzed baseline characteristics: sex, age, cardiovascular risk factors, history of stroke, and cortical/subcortical localization, arterial territory, number of lesions, and lesion size of the acute symptomatic infarction, together with the ROPE score. The presence and the number of acute and chronic SCCI lesions were assessed.
93 studies on the registry are indexed under Brain Infarction; 19 are open to participants now.
This study's enrollment of 50 is below the median of 477 across 23 observational studies indexed under Brain Infarction.
Browse Brain Infarction studies →Centre Hospitalier Universitaire de Nīmes is the lead sponsor of 595 studies on the registry; 90 are open to participants now.
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Consecutive young (\<60 years) cryptogenic stroke patients with PFO recruited between January 2016 and May 2019 in our center, and compared these patients with sex- and age-matched controls with cryptogenic stroke without PFO.
Inclusion Criteria:
Other: MRI scanner · Other: Contrast transoesophageal echocardiography
Other: MRI scanner · Other: Contrast transoesophageal echocardiography
MRI was performed with a 1.5T magnet (Ingenia, Philips, The Netherlands; diffusion-weighted imaging b-values = 0 and 1,000 s/mm2, TR 4,280 ms, and TE 97 ms). In case of technical problems with the 1.5T MRI scanner, a 3T magnet (Skyra, Siemens, Erlangen, Germany) was used. MRI was analyzed by an experienced rater (DR), blinded to clinical data and MRI sequences other than diffusion-weighted imaging.
Contrast transoesophageal echocardiography (including Valsalva manoeuvre)
number of infarction lesions
Number (increase)
Time frame: day 1
infarction location
anterior, posterior, or mixed anterior-posterior circulation and the cortical/subcortical/corticosubcortical location of infarction
Time frame: day 1
size of subcortical lesion
\< or \>15mm
Time frame: day 1
presence of multiterritorial infarction
mixed anterior-posterior circulation or bilateral anterior circulation
Time frame: day 1
Ran from Jul 2019 to primary completion in Dec 2019, 5 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Sep 2021. You cannot join it, but the record below documents what was studied.
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