A Phase 1/2 interventional study of midazolam in Acute Postoperative Pain, sponsored by Assiut University. Status unknown at 1 site in Egypt. Open to participants aged 20 Years to 70 Years. Per ClinicalTrials.gov, last updated 2021-02-24.
Sponsored by Assiut University · Phase 1/2, Interventional, and Treatment
this study aim to Compare the effect of preoperative Epidural Midazolam, Morphine and their combination in postoperative pain relief and total morphine consumption.
Major abdominal surgeries with abdominal incisions lead to severe abdominal pain, which if treated inadequately, can cause shallow breathing, atelectasis, retention of secretions and lack of cooperation in physiotherapy. This increases the incidence of post-operative morbidity and leads to delayed recovery.Epidural anesthesia is safe and inexpensive technique with the advantage of providing surgical anesthesia and prolonged postoperative pain relief. It also an effective treatment of operative pain blunts autonomic, somatic and endocrine responses. Morphine and midazolam can be used as adjuvant to bupivicain to reduced the postoperative pain
5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.
This study's planned enrollment of 20 is below the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →Assiut University is the lead sponsor of 4,901 studies on the registry; 2,098 are open to participants now.
Of its 13 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Bupivacaine 0.25% + midazolam 5mg in total volume 10m1
Drug: midazolam
Bupivacaine 0.25% + midazolam 5mg and morphine 5mg in total volume 10ml
Drug: midazolam
bupivacaine 0.25% + morphine 5 mg in total volume 10 ml
Drug: midazolam
epidural needle in the L1-2 or L2-3 space , and using loss of resistance technique udder strict aseptic condition 10 ml of the prepared drug will be given
Also known as: morphine, bupivacaine
time to first request of analgesia
the time between the end of operation and tracheal extubation to the first request for supplemental analgesics and its administration to the patient
Time frame: 1st 48 hours postoperative
the cumulative consumption of morphine in the 1st 48h postoperatively
total amount of morphine used for analgesia
Time frame: 1st 48 hours postoperative
This study is status unknown, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.
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Assiut University