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CompletedNCT04000893Updated Jun 27, 2019

Effect of Aerobic or Resistance Exercise on the Endothelial Response in Post-acute Myocardial Infarction Patients Submitted to Angioplasty

An interventional study of Resistance exercise session in Cardiac Rehabilitation, Aerobic Exercise and Resistance Exercise, sponsored by Instituto de Cardiologia do Rio Grande do Sul. Completed at 1 site in Brazil. Open to participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2019-06-27.

Sponsored by Instituto de Cardiologia do Rio Grande do Sul · Not applicable, Interventional, and Supportive care

From the registry’s dates

  • Registered 10 months after the study started (first participant enrolled Aug 2018, registered Jun 2019).
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
20 Years to 80 Years
Sex
All
01

Study summary

Cardiac Rehabilitation, as art and acting science multiprofessional, is based on the training with exercises that provides the post-infarct patients to satisfactorily re-establish the patient's clinical condition and that improve the functional capacity of these individuals.

Evidence shows that aerobic exercise training provides improvements in the endothelial function of this population. However, we do not yet have strong evidence of other modalities of exercise in these parameters in post-infarction patients treated with angioplasty.

02

Conditions studied

  • Cardiac Rehabilitation
  • Aerobic Exercise
  • Resistance Exercise
03

In context

Myocardial Infarction

2,744 studies on the registry are indexed under Myocardial Infarction; 418 are open to participants now.

This study's enrollment of 20 is below the median of 148 across 1,595 interventional studies indexed under Myocardial Infarction.

Browse Myocardial Infarction studies →

Lead sponsor

Instituto de Cardiologia do Rio Grande do Sul is the lead sponsor of 74 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Post-acute myocardial infarction patients
  • Ergometric test 30 days after the infarction
  • Ejection fraction> 40% (Simpson's method)
  • Regular use of optimized drugs

Exclusion criteria

Exclusion Criteria:

  • Unable to perform the randomized exercise
05

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
20 participants (actual)

Study arms

  • Experimental
    Resistance exercise session

    Acute isometric session, about 20 minutes.

    Other: Resistance exercise session

  • Active comparator
    Aerobic exercise session

    Acute aerobic session, about 20 minutes.

    Other: Resistance exercise session

Interventions

  • OtherResistance exercise session

    Acute isometric exercise session performed with handgrip Jamar about 20 minutes monitored.

    Also known as: Aerobic exercise session

06

What researchers measure

Primary outcomes

  1. Endothelial function

    Flow-mediated dilatation technique

    Time frame: Pre and post 5 minutes exercise session

Secondary outcomes

  1. Arterial stiffness

    Pulse wave velocity technique

    Time frame: Pre and post 5 minutes exercise session

07

Study locations

1 site
  • Alexandre Lehnen
    Porto Alegre, Rio Grande Do Sul 90620-001, Brazil
08

References and documents

Publications

  • Kollet DP, Marenco AB, Belle NL, Barbosa E, Boll L, Eibel B, Waclawovsky G, Lehnen AM. Aerobic exercise, but not isometric handgrip exercise, improves endothelial function and arterial stiffness in patients with myocardial infarction undergoing coronary intervention: a randomized pilot study. BMC Cardiovasc Disord. 2021 Feb 17;21(1):101. doi: 10.1186/s12872-021-01849-2. PubMed 33596832 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 27, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT04000893
Lead sponsor
Instituto de Cardiologia do Rio Grande do Sul
Responsible party
Sponsor
First posted
Jun 27, 2019
Start date
Aug 1, 2018
Primary completion
Jan 31, 2019
Completion
Jun 25, 2019
Last update
Jun 27, 2019

Study contacts

Alexandre Lehnen, PhD
principal investigator · Instituto de Cardiologia do Rio Grande do Sul

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2019. You cannot join it, but the record below documents what was studied.

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