An interventional study of IR Imaging and 3D Scanning in Breast Cancer, sponsored by University of Texas Southwestern Medical Center. Completed at 1 site in United States. Open to female participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-08-02.
Sponsored by University of Texas Southwestern Medical Center · Not applicable, Interventional, and Diagnostic
The primary objective of this study is to obtain infrared (IR) images and video and three-dimensional (3-D) scans of patients referred for biopsy based on the results of their diagnostic breast exam(s).
This research study is investigating infrared imaging (also referred to as infrared thermography, or digital infrared thermal imaging (DITI)) of breast cancer. The infrared images collected in this study will be used to construct a computational biothermal engineering model of the cancerous breast.
Patients will undergo standard breast cancer screening procedures as part of routine care at Parkland Comprehensive Breast Center. For any patients who are referred for biopsy based on the results of their breast cancer screening procedures, this research study will take infrared images of the patient. Patients will undergo infrared imaging prior to biopsy but will not delay biopsy or treatment; infrared images \& video may be recorded at biopsy visit. The biopsy will confirm/diagnose whether the patient has a benign or malignant condition.
The purpose of this research study is to obtain IR images, IR video, and 3-D scans of female patients' breasts (i.e., thermograms) who have been referred for biopsy based on the results of their diagnostic breast exams. These patients may be later diagnosed with a malignant or benign breast condition. The infrared images and video collected will be used to construct and validate a computational biothermal engineering model of breast cancer.
This research study does not involve any investigational drugs or treatments. This research study does not involve any FDA-approved drugs or devices.
In this research study, the equipment used (IR camera, 3-D scanner) will no be tested nor be used to diagnose or treat. Further, medical decisions will not be based on the use of these devices.
Infrared imaging (or digital thermal infrared imaging, DITI) is a non-invasive, non-contact, and harmless imaging procedure that measures the natural infrared radiation (body heat) emitted by the human body at normal 37°C body temperature. This procedure does not expose the patient to any radiation and is therefore entirely safe for the patient.
IR images and video will be obtained by IR equipment provided by University of Texas (UT) at Dallas researchers. IR equipment consists of an IR camera and ancillary equipment (e.g., tripod, computer, and vendor-provided IR image-processing software). The IR camera that will be used will be a commercial off-the-shelf product.
Additionally, a 3-D scanner will be used to obtain a 3-D surface contour map of the patient's breasts. This 3-D scanner is also non-invasive, non-contact, and does not expose the patient any radiation, similar to the IR camera. The 3-D scanner outputs a file format that is compatible with 3-D computer-aided design (CAD) software for engineering analysis.
12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.
This study's enrollment of 11 is below the median of 72 across 9,303 interventional studies indexed under Breast Neoplasms.
Browse Breast Neoplasms studies →University of Texas Southwestern Medical Center is the lead sponsor of 990 studies on the registry; 201 are open to participants now.
Of its 135 completed or terminated interventional studies of FDA-regulated products, 100 (74%) have results posted.
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Exclusion Criteria:
Patients with Breast Imaging-Reporting and Data System (BI-RADS) 4C or 5 diagnosis who have been referred for breast biopsy based on the results of their standard diagnostic breast exam will undergo IR and 3D imaging of the breasts.
Procedure: IR Imaging · Procedure: 3D Scanning
Subjects will undergo steady steady state and video IR imaging of the breasts.
Subjects will undergo 3D scanning of the breasts.
Spatial location of breast tumors
Researchers will use subjects' radiological imaging data to quantify the location of the tumor inside the breast, including mammography, ultrasound, and/or magnetic resonance imaging (MRI), for patients who are diagnosed with breast cancer. The tumor location will be measured. The tumor location will serve as an input for the computational model. No diagnostic assessments will be made from these data for this research study.
Time frame: Two years
3-D Surface contour maps of the breast
Researchers will use a 3-D scanning device to reconstruct the 3-D surface geometry of subjects' breasts. The surface geometry of subjects' breasts will be measured. The surface geometry will serve as an input for the computational model. No diagnostic assessments will be made from these data for this research study.
Time frame: Two years
Computational thermal model of breast cancer
Researchers will use study data to validate a computational biothermal engineering model of the cancerous breast. The computational model will model and simulate the internal thermodynamic and heat transfer processes inside the breast with cancer. The model outputs expected surface temperatures of the breast with cancer. The model will be constructed using commercial engineering software, ANSYS Fluent. No diagnostic assessments will be made from these data for this research study.
Time frame: Two years
This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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University of Texas Southwestern Medical Center