An observational study in Healthy Related, sponsored by The First Affiliated Hospital of Zhengzhou University. Recruiting at 1 site in China. Open to female participants aged 18 Years to 40 Years. Per ClinicalTrials.gov, last updated 2019-06-19.
Sponsored by The First Affiliated Hospital of Zhengzhou University · Observational
The Prospective Cohort Study for Primary Ovarian Insufficient Patients was set up to investigate the short- and long-term health consequences in Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, China.
Premature ovarian insufficiency (POI) is a rare cause of infertility in women affecting 1% of the population. It is characterized by amenorrhea, hypoestrogenism and elevated gonadotrophin levels in women younger than 40 years of age. Other than the reproductive outcome of these patients, the short- and long-term health consequences are still unknown.
Since last decade, Clinical Reproductive Medicine Management System/Electronic Medical Record Cohort Database (CCRM/EMRCD) has been used in Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, and Henan Province Key Laboratory for Reproduction and Genetics. Information of patients (POI, PCOS, Endometriosis, azoospermia, ect) were recorded comprehensively. The current project plans to recruit POI participants in our center. Biological samples, questionnaires and short/long term health data will be collected. The study is aimed to provide evidence for POI prognosis.
The First Affiliated Hospital of Zhengzhou University is the lead sponsor of 123 studies on the registry; 72 are open to participants now.
Counted across the registry records on this site, refreshed daily.
(1) younger than 40 years of age; (2) at least four or more months of amenorrhea, two or more instances in which the serum FSH level is > 40 U/L (i.e., two inspections at intervals of 1 month or more), with an oestradiol level of \<20pg/ml
Exclusion Criteria:
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FSH (Follicle stimulating hormone)
mIU/mL
Time frame: Change from Baseline FSH at each6 months
LH (luteinizing hormone)
mIU/mL
Time frame: Change from Baseline LH at each6 months
Estrogen
pg/ml
Time frame: Change from Baseline Estrogen at each6 months
Progesterone
ng/ml
Time frame: Change from Baseline Progesterone at each6 months
Volume of uterus and ovary
Record the Length (mm)\*Width (mm)\*Height (mm) of uterus, and each ovary
Time frame: Change from Baseline volume at each6 months
Plan to share: Undecided
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The First Affiliated Hospital of Zhengzhou University