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TerminatedNCT03986853Explor-AVDUpdated Aug 4, 2022

Exploration of Angiogenesis in Decompensated Developmental Venous Abnormalities

An interventional study of Blood sampling in Developmental Venous Anomaly, sponsored by Hopital Foch. Terminated at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-08-04.

Sponsored by Hopital Foch · Not applicable, Interventional, and Basic science

Why this study was terminated
Patient with rare disease

From the registry’s dates

  • Registered 1 year 5 months after the study started (first participant enrolled Jan 2018, registered Jun 2019).
Phase
Not applicable
Study type
Interventional
Enrollment
3
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of our study is to demonstrate by blood samples in situ in the vascular lesion (performed during any cerebral catheterization for an embolization of arteriovenous malformation) the existence of angiogenic growth factors and inflammatory factors that would confirm the decompensation of venous ischemia.

02

Conditions studied

  • Developmental Venous Anomaly
03

In context

Congenital Abnormalities

980 studies on the registry are indexed under Congenital Abnormalities; 177 are open to participants now.

This study's enrollment of 3 is below the median of 49 across 491 interventional studies indexed under Congenital Abnormalities.

Browse Congenital Abnormalities studies →

Lead sponsor

Hopital Foch is the lead sponsor of 208 studies on the registry; 21 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Main Inclusion Criteria:

  • Presenting a DVA requiring hyperselective catheterization
  • Having sign an informed consent form

Exclusion Criteria:

  • Presenting a contraindication to the realization of hyperselective cathterism
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
3 participants (actual)

Study arms

  • Experimental
    Blood sample

    Blood sampling Under general anesthesia

    Procedure: Blood sampling

Interventions

  • ProcedureBlood sampling

    Blood sampling under general anesthesia

06

What researchers measure

Primary outcomes

  1. Assessment of angiogenic and inflammatory growth factors

    The 1st factor studied is VEGF-A

    Time frame: 1 day

  2. Assessment of angiogenic and inflammatory growth factors

    The 2nd factor studied is VEGF-A

    Time frame: 1 day

  3. Assessment of angiogenic and inflammatory growth factors

    The 3rd factor studied is angiopoitin-2

    Time frame: 1 day

  4. Assessment of angiogenic and inflammatory growth factors

    The 4th factor studied is PDGF

    Time frame: 1 day

  5. Assessment of angiogenic and inflammatory growth factors

    The 5th factor studied is angiopoietin-like 4

    Time frame: 1 day

07

Study locations

1 site
  • Hôpital Foch
    Suresnes, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 4, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT03986853
Lead sponsor
Hopital Foch
Collaborators
Collège de France
Responsible party
Sponsor
First posted
Jun 14, 2019
Start date
Jan 11, 2018
Primary completion
Jan 11, 2021
Completion
Jan 11, 2021
Last update
Aug 4, 2022

Study contacts

Georges Rodesch
principal investigator · Hôpital Foch

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Aug 2022. You cannot join it, but the record below documents what was studied.

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Discussion

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