Dual-benefits of Aerobic and Resistance Training

• Age 60-75 years with no significant health issues or conditions that, in the investigator's opinion, would limit the subject's ability to complete the study per protocol or that would impact the capability to get an accurate measurement of study endpoints.
• Body mass index between 18.0 and 35 kg/m2.
• Willingness to maintain current diet and adhere to the intervention programs described for the study and willing to undergo all testing procedures.
• Able to read, understand, and complete study-related questionnaires
• Able to read and understand, and willing to sign the informed consent form (ICF).
• 6-minute walk distance of 450-725 meters for men and 400-675 meters for women.

Exclusion Criteria:

• Failure to provide informed consent.
• 6-minute walk distance below 450 meters or above 725 meters for men, below 400 meters or above 675 meters for women
• Any activities of daily living (ADL) disability (difficulty feeding, dressing, continence, bathing, toileting, and transferring).
• Lives in a nursing home or assisted living facility
• Known neuromuscular or neurological conditions affecting somatosensory or motor function or control (e.g., hemiplegia, multiple sclerosis, peripheral neuropathy, Parkinsons disease, Myasthenia Gravis, Ataxia, Apraxia, post-polio syndrome, mitochondrial myopathy, etc.).
• Unable to communicate because of severe hearing loss or speech disorder.
• Severe visual impairment, which would preclude completion of the assessments.
• Cancer requiring treatment currently or in the past 2 years (except primary non-melanoma skin cancer or in situ cervical cancer)
• Hospitalization (medical confinement for 24 hours), or immobilization, or major surgical procedure requiring general anesthesia within 12 weeks prior to screening, or any planned surgical procedures during the study period.
• Chronic or relapsing/remitting gastrointestinal disorders such as inflammatory bowel disease and irritable bowel syndrome.
• Known history of human immunodeficiency virus (HIV) antibody at screening.
• Use of systemic glucocorticoids.
• Any history of angina pectoris
• Any history of heart failure
• Any history of myocardial infarction
• Any coronary artery bypass graft or percutaneous coronary intervention
• Heart disease that limits exercise (valvular, congenital, ischaemic and hypertrophic cardiomyopathy)
• Complex ventricular arrhythmias or heart block
• Chronic obstructive pulmonary disease, cerebrovascular disease, or peripheral vascular disease
• Diabetes mellitus
• Severe neuropathy
• Mini-mental state exam score (MMSE) below 19
• Psychiatric conditions that warrant acute or chronic therapeutic intervention (e.g., major depressive disorder, bipolar disorder, panic disorder, schizophrenia) that in the investigators opinion may interfere with the conduct of study procedures
• Unable to undergo magnetic resonance imaging (MRI) (e. g. body containing any metallic medical devices or equipment, including heart pacemakers, metal prostheses, implants or surgical clips, any prior injury from shrapnel or grinding metal, exposure to metallic dusts, metallic shavings or having tattoos containing metallic dyes).
• Unable to reliably undergo exercise or strength tests described for this study.
• Participation in progressive resistance exercise 2 or more days/week for most weeks over the 24 weeks prior to screening, OR 150+ minutes of accumulated aerobic exercise each week for most weeks over the 24 weeks prior to screening.
• Current self-reported activity level that, in the investigator's opinion, is considered highly active for older adults
• Participation in any clinical trial within 12 weeks prior to screening.
• Limb amputation (except for toes) and/or any fracture within 24 weeks.
• Any disorder that will not allow completion of the motions required for resistance or aerobic exercise
• Conditions (such as myasthenia gravis, myositis, muscular dystrophy or myopathy, including drug-induced myopathy) leading to muscle loss, muscle weakness, muscle cramps or myalgia.
• Acute viral or bacterial upper or lower respiratory infection at screening
• Abnormal or uncontrolled blood pressure (BP) at the screening visit defined as BP > 170/100 mmHg. If taking anti-hypertensive medication, have to be on stable doses of medication for more than 3 months.
• Current or recent history (within 1 year of screen) of heavy alcohol consumption or drug abuse that in the investigators opinion may interfere with the conduct of study procedures.
• Reports being pregnant, lactating, or that they anticipate becoming pregnant in the next 3-months. If a woman becomes pregnant while on study protocol they will be withdrawn from the study

Prohibited Medications: Medications that, in the PIs opinion, would confound study integrity by interacting with study outcomes. For instance:

• Anti-obesity drugs, nutraceuticals, and dietary supplements that may affect body mass and body composition.
• Any drug or supplement known to influence muscle mass or performance including but not limited to anabolic steroids, insulin-like growth factor 1 (IGF-1), growth hormone (GH), replacement androgen therapy, anti-androgen therapy.