ClinicalTrials.gg
CompletedNCT06602973Updated Apr 30, 2026

Relationships Between Exercise and Appetite in Women With Loss of Control Eating

An interventional study of Rest and Fed Exercise in Eating Disorders, Binge-Eating Disorder and Bulimia Nervosa, sponsored by Ohio University. Completed at 1 site in United States. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2026-04-30.

Sponsored by Ohio University · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
28
Allocation
Randomized
Ages
18 Years to 45 Years
Sex
Female
01

Where this study stands

Counted across the records on this site · 2026-11-12

Among 259 studies in Feeding and Eating Disorders with a site in United States — 36 open to participants now, 50 under way, none of them phase 3. Feeding and Eating Disorders · United States.

Enrollment
158th of 215
28 · median 66
Started
2024
with 15 others
No phase
169 of 259
29 open now
Registered
229th of 259
by date

Among the 259 studies in Feeding and Eating Disorders with a site in United States, this one is the 158th largest by enrollment of the 215 interventional ones that give a count, is one of 16 that started in 2024, is one of 169 with no phase, and was the 229th registered.

Feeding and Eating Disorders

645 studies on the registry are indexed under Feeding and Eating Disorders; 153 are open to participants now.

Browse Feeding and Eating Disorders studies →

Open to participants now

36 of the 259 studies in Feeding and Eating Disorders with a site in United States are open now. Recruiting first, the newest first:

31 more — sign in →

All 36 open studies →

A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →

Who these studies take

Of the 101 Feeding and Eating Disorders studies recruiting now, 31 (31%) set no upper age limit and 68 (67%) stop at 75 or younger; 46 take children under 18; 21 take healthy volunteers.

This study: 18 Years to 45 Years · female · no healthy volunteers.

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02

Study summary

This pilot study is a first step in looking at the relationship between exercise and appetite in women with loss of control eating.

03

Conditions studied

  • Eating Disorders
  • Binge-Eating Disorder
  • Bulimia Nervosa

Keywords

  • exercise
  • eating disorders
04

Who can participate

Ages eligible
18 Years to 45 Years
Sexes eligible
Female
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Engage in loss of control eating at least 12 times in the last three months
  • eating disorder-related impairment (CIA > 15)
  • Minimum VO2max of 50th percentile for age and sex assigned at birth
  • Be willing to eat study-provided foods
  • Likes chocolate (at least 6/10 on 10 point scale)

Exclusion criteria

Exclusion Criteria:

  • \< 18.5 kgm/2
  • Medical conditions that affect appetite or weight (e.g., diabetes mellitus, thyroid disease)
  • Recent pregnancy or breastfeeding (prior 6 months)
  • Relevant food allergies (e.g., wheat, chocolate)
  • Specific phobia, blood-injection-injury type
  • Medical condition that precludes safe participation in exercise (e.g., stress fracture)
  • Medications that acutely affect appetite (e.g., GLP-1 agonists; psychiatric medications allowed)
Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Clinically significant

Judged by the study doctor to matter for your health or for the study. It is a doctor’s decision, so ask the study team if you are unsure whether something counts.

BMI (body mass index)

Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.

What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.

05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
28 participants (actual)

Study arms

  • Experimental
    Rest, Fed Exercise, Fasted Exercise

    At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will abstain from breakfast and will engage in exercise.

    Behavioral: Rest · Behavioral: Fed Exercise · Behavioral: Fasted Exercise

  • Experimental
    Rest, Fasted Exercise, Fed Exercise

    At Study Visit 2, participants will eat breakfast and rest (abstain from exercise). At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and exercise.

    Behavioral: Rest · Behavioral: Fed Exercise · Behavioral: Fasted Exercise

  • Experimental
    Fed Exercise, Rest, Fasted Exercise

    At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will abstain from breakfast and will engage in exercise.

    Behavioral: Rest · Behavioral: Fed Exercise · Behavioral: Fasted Exercise

  • Experimental
    Fed Exercise, Fasted Exercise, Rest

    At Study Visit 2, participants will eat breakfast and exercise. At Study Visit 3, participants will abstain from breakfast and will engage in exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise).

    Behavioral: Rest · Behavioral: Fed Exercise · Behavioral: Fasted Exercise

  • Experimental
    Fasted Exercise, Fed Exercise, Rest

    At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and exercise. At Study Visit 4, participants will eat breakfast and rest (abstain from exercise)

    Behavioral: Rest · Behavioral: Fed Exercise · Behavioral: Fasted Exercise

  • Experimental
    Fasted Exercise, Rest, Fed Exercise

    At Study Visit 2, participants will abstain from breakfast and will engage in exercise. At Study Visit 3, participants will eat breakfast and rest (abstain from exercise). At Study Visit 4, participants will eat breakfast and exercise.

    Behavioral: Rest · Behavioral: Fed Exercise · Behavioral: Fasted Exercise

Interventions

  • BehavioralRest

    Participants will eat breakfast but abstain from exercise

  • BehavioralFed Exercise

    Participants will eat breakfast and engage in 30 minutes of physical activity at 75% of their personal V02max.

  • BehavioralFasted Exercise

    Participants will engage in 30 minutes of physical activity at their personal 75% V02max after abstaining from breakfast.

06

What researchers measure

Primary outcomes

  1. Relative Energy Intake

    Relative energy intake for 24 hours will be calculated as absolute energy intake from the breakfast (if consumed), lunch, food reward value task, and take home cooler minus energy expenditure during exercise (or comparable time period during rest).

    Time frame: Food intake from 8 am to 8 am; Energy expenditure from approximately 9 am to 9:05 am and 9:25 to 9:30 am, coinciding with study condition (rest or exercise)

Secondary outcomes

  1. Lactate

    Lactate values

    Time frame: 30 minutes, pre-post exercise (or rest)

  2. Acylated ghrelin

    Acylated ghrelin

    Time frame: Immediately prior to lunch

  3. Self-reported binge eating

    Participants will rate the extent the following questions, considering the time frame "since yesterday morning at 8 am" on a 1 to 5 scale from "not at all" to "extremely": "While you were eating, to what extent did you feel a sense of loss of control?," "While you were eating, to what extent did you feel that you could not resist eating," "While you were eating, to what extent did you feel that you could not stop eating once you had started," and "While you were eating, to what extent did you feel driven or compelled to eat?" An answer of 4 or higher on any item will be categorized as binge eating present. Any reported binge eating on either day will be coded as binge eating being present

    Time frame: 24 and 48 hours after exercise/rest study visit

  4. Food reward value

    Number of trials according to task developed by Bodell and Keel 2015

    Time frame: Approximately 3:30 pm day of study visit

07

Study locations

1 site
  • Ohio University
    Athens, Ohio 45701, United States
08

References and documents

Individual participant data

Plan to share: Undecided — Data may be shared on a public repository, such as the Open Science Framework

No publications or documents are linked to this record.

09

Timeline

Tracking since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Ran from Aug 2024 to primary completion in Apr 2026, 19 months.

Of 269 non-industry interventional studies with no phase under Feeding and Eating Disorders, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 14 and three quarters within 49. This study's 19 months is below that.

Counting every sponsor, half of 274 studies reached it within 28 months; a quarter within 14 and three quarters within 49.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 12, 2024
First posted
Sep 19, 2024
StartActual
Aug 30, 2024
Primary completionActual
Apr 21, 2026
CompletionActual
Apr 21, 2026
Last update
Apr 30, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 30, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT06602973
Lead sponsor
Ohio University
Responsible party
Katherine J. Forney (Assistant Professor, Ohio University) — Principal investigator
First posted
Sep 19, 2024
Start date
Aug 30, 2024
Primary completion
Apr 21, 2026
Completion
Apr 21, 2026
Last update
Apr 30, 2026

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.

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