Status unknownNCT03978013Updated Jun 6, 2019

Pomegranate Juice Effect on Oxidative Stress in Infertile Women During IVF Treatment

An interventional study of Pomegranate juice and Apple juice in PCOS, Endometriosis and Advised Maternal Age, sponsored by Rambam Health Care Campus. Status unknown. Open to female participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-06-06.

Sponsored by Rambam Health Care Campus · Not applicable, Interventional, and Supportive care

The sponsor has not verified this record recently (last verified Jun 2019), so the status shown — last known as Not yet recruiting — may be out of date.

Phase: Not applicable
Study type: Interventional
Enrollment: 40
Allocation: Randomized
Ages: 18 Years to 45 Years
Sex: Female

Study summary

tTe investigators estimate pomegranate supplementation effect on oxidative stress in infertile women with PCOS, endometriosis and advanced maternal age during IVF treatment. The primary aim is to compare the obtained oxidative stress markers in follicular fluid with pomegranate supplementation vs control.

Conditions studied

PCOS
Endometriosis
Advised Maternal Age
Male Factor Infertility

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In context

Infertility

2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.

This study's planned enrollment of 40 is below the median of 120 across 1,698 interventional studies indexed under Infertility.

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Lead sponsor

Rambam Health Care Campus is the lead sponsor of 456 studies on the registry; 33 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 45 Years
Sexes eligible: Female
Accepts healthy volunteers: Yes

Inclusion criteria

Patients undergo IVF treatment with diagnosis of PCOS/Endometriosis/MF or AMA

Exclusion criteria

Exclusion Criteria:

Patients who do not meet the inclusion criteria, as above

Study design

Phase: Not applicable
Primary purpose: Supportive care
Allocation: Randomized
Intervention model: Parallel assignment
Masking: Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment: 40 participants (estimated)

Study arms

Experimental
Pomegranate
Other: Pomegranate juice
Active comparator
Apple
Other: Apple juice

Interventions

OtherPomegranate juice
Pomegranate juice
OtherApple juice
Apple juice

What researchers measure

Primary outcomes

Cytokines levels in follicle fluid
Cytokines (pg/mL) will be mesured by elisa.
Time frame: 2 weeks

Study locations

No study locations are listed for this record.

References and documents

Individual participant data

Plan to share: Yes

Supporting information: Study protocol, Sap, Icf, Csr, Analytic code

No publications or documents are linked to this record.

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Jun 6, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT03978013
Lead sponsor: Rambam Health Care Campus
Responsible party: Ola Gutzeit MD (Principal Investigator, Rambam Health Care Campus) — Principal investigator
First posted: Jun 6, 2019
Start date: Sep 1, 2019 (estimated)
Primary completion: Dec 1, 2020 (estimated)
Completion: Dec 1, 2021 (estimated)
Last update: Jun 6, 2019

Oversight

Data monitoring committee: Yes
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jun 2019. You cannot join it, but the record below documents what was studied.

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