An interventional study of Grape seeds extract and Casein-phosphopeptide/amorphous-calcium phosphate in Dental Caries, sponsored by Cairo University. Status unknown. Open to participants aged 13 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-05-29.
Sponsored by Cairo University · Not applicable, Interventional, and Treatment
Assess the effectiveness of applying grape seed extract (GSE) gel versus casein phosphopeptide-amorphous calcium phosphate (MI) paste on remineralization of white spot lesion (WSLs) in post orthodontic patients.
The development of WSLs is a challenging problem in the track of orthodontic treatment. Especially in patients wearing fixed orthodontic appliances, plaque accumulation increases around brackets and bands and the pH on dental surfaces becomes acidic.
These early lesions are willing to remineralization, arrest, reharden and revert to healthy enamel condition through a remineralization process involving the diffusion of minerals into the defective tooth structure. For this purpose various remineralizing agents such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and grape seed extract (GSE) have been used.
This research is conducted for early intervention and treatment of the white spot lesions by non-invasive method.
1,109 studies on the registry are indexed under Dental Caries; 197 are open to participants now.
This study's planned enrollment of 24 is below the median of 60 across 916 interventional studies indexed under Dental Caries.
Browse Dental Caries studies →Cairo University is the lead sponsor of 4,780 studies on the registry; 1,427 are open to participants now.
Of its 36 completed or terminated interventional studies of FDA-regulated products, 5 (14%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Every week the grape seeds extract (gel) put into the tray and apply it to the upper teeth of the participant.
Other: Grape seeds extract
CPP-ACP paste apply to the teeth twice daily.
Other: Casein-phosphopeptide/amorphous-calcium phosphate
Grape seeds extract powder
CPP-ACP paste
Quantitative changes of white spot lesions
changes in fluorescence of white spot lesions will be evaluated after reminerlization by using diagnodent device by score (0-20).
Time frame: evaluation of tooth surface changes at baseline and at 4, 12, and 24 weeks after starting treatment .
No study locations are listed for this record.
This study is status unknown, as verified in May 2019. You cannot join it, but the record below documents what was studied.
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Cairo University