An observational study in Diabetes Mellitus, Type 2, Diabetic Nephropathies and Chronic Kidney Diseases, sponsored by Karolinska University Hospital. Suspended at 1 site in Sweden. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-03-19.
Sponsored by Karolinska University Hospital · Observational
Because the atherosclerosis process partly occur in the intercellular space of the vessel wall, the determination of the constitution of lipoproteins in the interstitial fluid may expand the knowledge about the atherosclerosis process and lead to a better understanding of what constitutes the increased risk of developing cardiovascular disease in patients with chronic diseases. The investigators hypothesize that the apoB-containing particles in T2D patients are more susceptible to be retained or consumed in the intercellular compartment, which in turn could be one explanation for the elevated risk of atherosclerosis. The investigators hypothesise that with the progression of chronic kidney disease this process is further increased. Patients undergoing dialysis are known to have a very high risk of cardiovascular disease. The investigators now want to study the cholesterol metabolism in interstitial fluid in subjects undergoing hemodialysis because of diabetic nephropathy and in subjects undergoing hemodialysis because of chronic kidney disease of other causes.
3,840 studies on the registry are indexed under Kidney Diseases; 500 are open to participants now.
This study's planned enrollment of 20 is below the median of 192 across 1,033 observational studies indexed under Kidney Diseases.
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Diabetic nephropathy, because of type 2 diabetes, undergoing hemodialysis and subjects with chronic kidney disease of other causes undergoing hemodialysis.
Diabetic nephropathy, because of type 2 diabetes, undergoing hemodialysis and subjects with chronic kidney disease of other causes undergoing hemodialysis.
Exclusion Criteria:
Chronic kidney disease of other causes than Diabetes.
Renal outpatients at Nephrology Unit, Karolinska University Hospital Huddinge
Renal outpatients at Nephrology Unit, Karolinska University Hospital Huddinge
Interstitial fluid-to-serum ratio for LDL cholesterol
Time frame: 2 hours
Plan to share: No
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This study is suspended, as verified in Mar 2025. You cannot join it, but the record below documents what was studied.
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Karolinska University Hospital