An observational study in Brain Hypoxia Ischemia, sponsored by Western University, Canada. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-01-27.
Sponsored by Western University, Canada · Observational
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Among 19 studies in Hypoxia-Ischemia, Brain with a site in Canada — 10 open to participants now, 10 under way, none of them phase 3. Hypoxia-Ischemia, Brain · Canada.
Among the 19 studies in Hypoxia-Ischemia, Brain with a site in Canada, this one is the only one that started in 2019, is one of 5 observational ones, and was the 7th registered.
261 studies on the registry are indexed under Hypoxia-Ischemia, Brain; 94 are open to participants now.
Browse Hypoxia-Ischemia, Brain studies →10 of the 19 studies in Hypoxia-Ischemia, Brain with a site in Canada are open now. Recruiting first, the newest first:
University of Alberta · Sites in Canada
Ages 1 days–1 days
McGill University Health Centre/Research Institute of the McGill University Health Centre · Sites in Canada
University of Calgary · Sites in Canada
Pia Wintermark · Sites in Canada, United States
Ages 0 min–48 hrs
Hamilton Health Sciences Corporation · Sites in Canada
Ages 1 days–15 days
A study can be open while its sites in Canada have not opened yet or have stopped. Only those recruiting at a site in Canada →
Of the 60 Hypoxia-Ischemia, Brain studies recruiting now, 21 (35%) set no upper age limit and 37 (62%) stop at 75 or younger; 46 take children under 18; 7 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
19 studies; the count open now beside each. This study's row is marked.
First in 2009; this study’s year is marked. 1 started in 2019.
By drug class, each counting the studies that test any of its medicines:
This study's enrollment of 50 is below the median of 89 across 92 observational studies indexed under Hypoxia-Ischemia, Brain.
Median enrollment 42 across the 14 interventional studies, 50 across the 5 observational. Of the 9 that completed or were terminated, 3 (33%) have results posted.
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1 of 19 have an industry lead sponsor. The 10 most frequent:
Western University, Canada is the lead sponsor of 224 studies on the registry; 56 are open to participants now.
Western University, Canada has 1 study filed under Hypoxia-Ischemia, Brain — fewer than ten, so there is no comparison to draw.
2 of the studies in Hypoxia-Ischemia, Brain with a site in Canada that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07829887University of CalgaryCerebral Oximetry in Management of Post Cardiac Arrest | 2027-02 |
| NCT06985290Ipsita GoswamiDexmedetomidine Versus Morphine During Cooling Therapy in Neonates | 2027-09-30 |
Add all 2 to your calendar (.ics) → With an account.
Among the 19 studies in Hypoxia-Ischemia, Brain with a site in Canada, from their registry updates:
This tab as a report to print or save as PDF → With an account.
This study uses a CPOM Optical neuromonitor to assess the relationship between brain cytochrome C oxidase, cerebral oxygen saturation and blood pressure during surgery performed under general anesthesia.
During various surgical procedures, blood supply to the brain can be jeopardized either due to interruption of flow as occurs during carotid surgery, or due to inadequate arterial pressure which can occur in settings as diverse as heart surgery or shoulder surgery. This is a prospective observational study of brain oxygen levels, brain metabolism and blood pressure in 50 adult surgical patients under general anesthesia using a CPOM Optical neuromonitor.
This is an observational study. The primary objective of this study is to describe the changes in redox state of brain CCO (reflecting oxidative metabolism), CBFi, and brain tissue oxygen saturation in relation to systemic blood pressure in patients during general anesthesia/cardiopulmonary bypass (CPB). This study represents the first opportunity to assess this combined technology in adult patients and will provide important data to support further investigations in brain-at-risk patients.
These 50 patients will be used to help the investigators to obtain pilot data about the relationship between brain cytochrome C oxidase (bCCO), cerebral oxygen saturation (ScO2), and blood pressure (especially hypotension) using a CPOM device. Cerebral auto regulation indices will also be determined. No intervention will be applied.
Patients admitted for surgery requiring general anesthesia and required to have an arterial line.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Prior to induction of anesthesia, the CPOM monitor will be secured to the temporal region of the participant's forehead to measure and record the cerebral hemodynamic data before, during, and following intubation. Hemodynamic, respiratory, body temperature, and anesthetic data will be continuously digitally records. The CPOM device will be detached after extubation in the operative room.
Brain cytochrome C oxidase level.
The cytochrome C oxidase level which reflects the brain oxidative metabolism will be measured by a CPOM Optical Neuromonitor.
Time frame: Intraoperative
Brain saturation (ScO2)
The brain saturation (ScO2) (%) will be measured by a CPOM Optical Neuromonitor.
Time frame: Intraoperative
Ran from Jul 2019 to primary completion in Feb 2023, 43 months.
Of 46 non-industry observational studies under Hypoxia-Ischemia, Brain, half reached primary completion within 43 months of starting (the median), counting those still running; a quarter within 20. This study's 43 months is close to that.
Counting every sponsor, half of 50 studies reached it within 43 months; a quarter within 20.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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