An interventional study of Fresh pomegranate juice in Patients With Type 2 Diabetes (FSG: More Than 7.1 and Not Higher Than 15.8 mmol/L), sponsored by Jordan University of Science and Technology. Completed at 1 site in Jordan. Open to participants aged 35 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-04-04.
Sponsored by Jordan University of Science and Technology · Not applicable, Interventional, and Treatment
Fresh pomegranate juice at 1.5 mL/kg of body weight was administered by recruited healthy individuals and patients with type 2 diabetes of fasting serum glucose between 7.1 and 15.8 mmol/L after approximately 12 hours fasting. Blood samples were collected in plain tubes before (-5 minutes) and at 1 and 3 hours after drinking pomegranate juice. Blood samples were centrifuged and serum was collected and stored for glucose and hormonal analysis. Patients were recruited from those of earlier stages of type 2 diabetes, and many of them already drink pomegranate juice as of its benefits for their health).
The exclusion criteria included subjects with renal or hepatic disease, pregnancy, treatment with insulin, and hormone therapies. Participants who had either smoked cigarettes or taken antioxidant supplements, lipid-lowering drugs, and oral hypoglycemic agents, such as metformin (glucophage) or sulfonylureas, within the preceding 12 hours were also excluded.
The study was explained to all of the recruited subjects by the clinical researchers, and written informed consent was obtained prior to enrollment. Approval for the study was provided by the IRB Committee at Jordan University of Science and Technology (Irbid, Jordan).
9,359 studies on the registry are indexed under Diabetes Mellitus, Type 2; 1,318 are open to participants now.
This study's enrollment of 85 is close to the median of 80 across 7,525 interventional studies indexed under Diabetes Mellitus, Type 2.
Browse Diabetes Mellitus, Type 2 studies →Jordan University of Science and Technology is the lead sponsor of 88 studies on the registry; 7 are open to participants now.
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Exclusion Criteria:
Patients with type 2 diabetes at early stages of type 2 diabetes (FSG: 7.1 15.8 mmol/L)
Other: Fresh pomegranate juice
Healthy individuals match age and gender to the experimental group
Other: Fresh pomegranate juice
Pomegranate seeds (arils) were separated by hand, and fresh pomegranate juice was prepared by squeezing the seeds using a fruit squeezing machine. Fresh pomegranate juice was given at 1.5 mL/kg of body weight for the fasted recruited patient with type 2 diabetes (FSG \< 15.8 mmol/L). Blood was collected before and after 1 and 3 hours of ingesting the juice.
Fasting serum glucose measurement
Measuring the alteration in fasting serum glucose in mmol/L before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Insulin hormone measurement
Measuring insulin in μIU/mL before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Erythropoietin hormone measurement
Measuring erythropoietin in mIU/mL before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Thyroxine hormone measurement
Measuring erythropoietin in μg/dL before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Cortisol hormone measurement
Measuring erythropoietin in nmol/L before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 -3 hours
Melatonin hormone measurement
Measuring Melatonin in pg/mL before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Testosterone hormone measurement
Measuring testosterone in ng/dL before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Aldosterone hormone measurement
Measuring aldosterone in ng/dL before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Serum total antioxidant activity measurement
Measuring serum total antioxidant activity in Trolox equivalents before and at 1 and 3 hours following pomegranate juice ingestion
Time frame: 1 - 3 hours
Plan to share: No
This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
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Jordan University of Science and Technology