An interventional study of Reinforced multidisciplinary follow-up in Heart Failure, sponsored by University Hospital, Montpellier. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-04-03.
Sponsored by University Hospital, Montpellier · Not applicable, Interventional, and Other
This is a controlled, randomized, open-label, multicentric study evaluating the value of coordinated medico-pharmaceutical management compared to standard management in patients with heart failure. The aim of this study is to evaluate the impact of these optimized activities on the re-hospitalization of the patient with cardiac insufficiency for a disease-related event within three months of the initial hospitalization.
Heart failure (FH) is a public health problem with an estimated prevalence of about 1.5% in developed countries. In 2013, the number of patients hospitalized in France for heart failure amounted to 165 231 and 20% of them were re-hospitalized at least once for the same reason during this year. Several factors contribute to the occurrence of cardiac decompensation (DC) : some modifiable (age, severity of IC, etiology ...) and others modifiable, such as therapeutics. Various elements could reduce the frequency of re-hospitalizations and the mortality due to this disease :
5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.
This study's enrollment of 229 is above the median of 72 across 3,736 interventional studies indexed under Heart Failure.
Browse Heart Failure studies →University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Entrance medication reconciliation performed by a pharmacist * Patient compliance evaluation * Patient quality of life evaluation * Pharmaceutical analysis with focus on medication optimization with a specific check-list (according to ESC 2016 recommendations) * Hospitalisation discharge medication reconciliation * Patient pharmaceutic interview at the hospitalisation discharge * Transmission of informations to the general practitioner and the pharmacist's patient * Multidisciplinary consult at 1 month after hospitalisation discharge
Other: Reinforced multidisciplinary follow-up
* Drug review by a paramedic or a pharmacist * Pharmaceutical analysis * Therapeutic optimisation based on the usual practices care of the cardiologic department * Writing of the prescription given on leaving hospital based on the usual care of the department * Treatments explanations and support to the patient on the usual care * Transmission of the hospitalisation report to the patient general practitioner as the usual practice * Medical consult in usual time frames (an average of 1 month after hospitalisation discharge) at the patient location of choice
Reinforced multidisciplinary follow-up
Rehospitalisation for heart failure
At least one rehospitalisation with heart failure related cause
Time frame: Call at 3 months after hospitalisation discharge
Prescriptions conformity rates compared to heart failure recommendations edited by the European Society of Cardiology in 2016
Evaluated by a pharmacist
Time frame: At hospitalisation discharge (Day 0)
Prescriptions conformity rates compared to heart failure recommendations edited by the European Society of Cardiology in 2016
Evaluated by a pharmacist
Time frame: Call at 3 months after hospitalisation discharge
Compliance level
Evaluated by the " Girerd medication adherence questionnaire " The " Girerd medication adherence questionnaire " contains 6 questions which answers are " yes " or " no ". The number of " yes " responses permits to evaluate the level of the patient medication adherence as following : 0 yes : good compliance 1 or 2 yes : minor non compliance 3 or more yes : non compliance
Time frame: At hospitalisation discharge (Day 0)
Compliance level
Evaluated by the "Girerd medication adherence questionnaire" Evaluated by the " Girerd medication adherence questionnaire " The " Girerd medication adherence questionnaire " contains 6 questions which answers are " yes " or " no ". The number of " yes " responses permits to evaluate the level of the patient medication adherence as following : 0 yes : good compliance 1 or 2 yes : minor non compliance 3 or more yes : non compliance
Time frame: At 1 month after hospitalisation discharge for the experimental group only
Compliance level
Evaluated by the "Girerd medication adherence questionnaire" Evaluated by the " Girerd medication adherence questionnaire " The " Girerd medication adherence questionnaire " contains 6 questions which answers are " yes " or " no ". The number of " yes " responses permits to evaluate the level of the patient medication adherence as following : 0 yes : good compliance 1 or 2 yes : minor non compliance 3 or more yes : non compliance
Time frame: Call at 3 months after hospitalisation discharge
Treatment persistence rates
Evaluated by a pharmacist
Time frame: Call at 3 months after hospitalisation discharge
Death rate
Evaluated by a pharmacist
Time frame: Call at 3 months after hospitalisation discharge
Time before death
Evaluated by a pharmacist
Time frame: Call at 3 months after hospitalisation discharge
Time of occurrence of a potential rehospitalisation related to the disease
Evaluated by a pharmacist
Time frame: Call at 3 months after hospitalisation discharge
Quality of life score
Evaluated by the Minnesota Living with Heart Failure Questionnaire the Minnesota Living with Heart Failure Questionnaire contains 21 questions. Each of the 21 questions ask the patients to indicate how much a possible effect of heart failure have affected their ability to live as wanted during the past month using a scale from 0 (not present or no effect), 1 (very little), 2, 3, 4, or 5 (very much).The measurement of heart failure severity is assessed by summing the responses that ranges from 0 to 105.
Time frame: Call at 3 months after hospitalisation discharge
Satisfaction of the patient
Evaluated by Likert scale This questionnaire indicates the degree of patient satisfaction using 9 questions which explore the improvement of patient behavior concerning disease and treatment. The measurement of satisfaction is assessed by summing the responses that range from 9 (unsatisfied) to 36 (very satisfied)
Time frame: Call at 3 months after hospitalisation discharge
Satisfaction of health professionals
Evaluated by Likert scale (only for interventional arm) This questionnaire indicates the degree of health professional satisfaction using 6 questions which explore the improvement of transition between hospital to community and comprehension of therapeutic optimization. The measurement of satisfaction is assessed by summing the responses that range from 6 (unsatisfied) to 24 (very satisfied)
Time frame: online questionnaire at 3 months after hospitalisation discharge
Incremental cost-effectiveness ratio
Time frame: 3 months after hospitalisation discharge
This study is completed, as verified in Apr 2026. You cannot join it, but the record below documents what was studied.
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University Hospital, Montpellier