An observational study in Attention Deficit Hyperactivity Disorder, sponsored by National Taiwan University Hospital. Status unknown at 1 site in Taiwan. Open to participants aged 7 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-05-03.
Sponsored by National Taiwan University Hospital · Observational
The present project is to identify the relationship between ADHD and the metabolites of tryptophan.
Because attention deficit hyperactivity disorder (ADHD) is an early onset and long-term impairing disorder with tremendous impact on individuals, families, and societies, detection and diagnosis are very important for ADHD. According to investigators previous work, participants with ADHD have executive dysfunction. Previous studies show that tryptophan is associated with cognitive problems in participants. Analyzing differences in tryptophan metabolites (Indolepropionic acid [IPA], indoleacetic acid [IAA], and kynurenic acid [KYNA]) between participants with ADHD and healthy controls could provide insight into underlying disease pathology of cognitive deficits. In this one-year project, investigators will perform an analysis of tryptophan metabolites in serum to identify potential biomarkers for the executive dysfunction of ADHD.
729 studies on the registry are indexed under Hyperkinesis; 25 are open to participants now.
This study's planned enrollment of 240 is above the median of 134 across 122 observational studies indexed under Hyperkinesis.
Browse Hyperkinesis studies →National Taiwan University Hospital is the lead sponsor of 2,563 studies on the registry; 569 are open to participants now.
Of its 11 completed or terminated interventional studies of FDA-regulated products, 2 (18%) have results posted.
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120 drug-naïve patients with ADHD, aged 7 to 18 years, will be enrolled. Another 120 healthy participants with matched age and sex will be enrolled in the control group.
The ADHD group
Inclusion Criteria
Patients with ADHD are eligible to be included in this study only if they meet all of the following criteria:
Patients will be excluded from the study if they meet any of the following criteria:
drug-naive patients with ADHD, aged 7-18 year old
drug-naive healthy controls, aged 7-18 year old
Serum level of Indolepropionic acid [IPA]
tryptophan metabolite
Time frame: 1 year
Serum level of indoleacetic acid [IAA]
tryptophan metabolite
Time frame: 1 year
Serum level of kynurenic acid [KYNA]
tryptophan metabolite
Time frame: 1 year
ADHD Rating Scale-IV
behavioral measures
Time frame: 1 year
Swanson, Nolan, and Pelham IV scale
The SNAP-IV is a 26-items scale, consisting of the DSM-IV symptoms for the Inattention (Item 1-9) and the Hyperactivity/Impulsivity domains (Item 10-18) of the criteria for ADHD, and the oppositional symptoms (Item 19-26) of the criteria for ODD (20). As in the DSM-IV criteria, to describe psychopathology, the word "often" is included at the beginning of each item, so the precise interpretation of the 4-point rating scale (0 = "not at all", 2 = "just a little", 3 = "quite a bit", and 4 = "very much") reflects the degree that the behavior is abnormally frequent and severe compared to normal childhood behavior.
Time frame: 1 year
Achenbach Child Behavior Checklist
designed to assess the competencies and behavioral/emotional problems in children 4-18 for CBCL. rate how true each item is at present or within the last 6 months, using a 3-point response scale. subdivided into a profile report on child's standing in competence items and in 112 problem items. Internalizing score is composed of scores for anxiety/depression, somatic complaints, and withdrawal. Externalizing score is comprised of scores for delinquent behavior and aggressive behavior.
Time frame: 1 year
Clinical Global Impressions-ADHD-Severity
The CGI-ADHD-S (120) is a single item clinician rating of the assessment of the global severity of the ADHD symptoms in relation to the clinician's total experience with ADHD patients. Severity is rated on a 7-point scale (1=normal, not at all ill; 7=among the most extremely ill patients). The CGI-ADHD-S will be administered on each visit, from visit 1 through visit 10.
Time frame: 1 year
Social Adjustment Inventory for Children and Adolescents
The SAICA is a 77-item semi-structured interview scale that was designed for administration to school-aged children aged 6-18 about themselves, or to their parents about their children (121). The SAICA provides an evaluation of children's current functioning in the domains of (1) school, (2) spare time, (3) peer relations, and (4) home behaviors. A higher mean score (items rated on 4-point Likert scale from 1 to 4) indicates either poorer social function or a more severe social problem (121). (We delete the Spare time relationship in the Overall relationship) The score for each item ranges from 1 to 4. An increased score indicates either a decreased social function or an increased severity of social problem.
Time frame: 1 year
Chinese version of the Family Adaptation, Partnership, Growth, Affection, and Resolve
behavioral measures
Time frame: 1 year
Cambridge Neuropsychological Test Automated Batteries
neuropsychological measures
Time frame: 1 year
Continuous Performance Test
neuropsychological measures
Time frame: 1 year
This study is status unknown, as verified in Nov 2018. You cannot join it, but the record below documents what was studied.
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National Taiwan University Hospital