An interventional study of functional MRI and Automated Cortical Brainstem Auditory Evoked Potential in Auditory Processing Disorders, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 7 Years to 18 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-23.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Diagnostic
Auditory Processing Disorder (APD) affects 0.5-7% of the pediatric population. This disorder is responsible for a child's low hearing ability. The diagnosis of APD is difficult because of polymorphic symptoms possibly entangled with other difficulties (learning, communication, attention ...). There is currently no gold standard in the literature for diagnosing APD. Investigators opened multidisciplinary consultation for the children suspected of APD. The purpose of this study is to analyze the results of the multidisciplinary assessment performed on these children (audiometry, cortical auditory brainstem response (ABR), behavioral assessment, psychometric evaluation, genetic analysis) to the results of functional MRI (fMRI) at rest and in activation. The goal is to find radiological MRI-fMRI markers in these patients that improve the diagnosis of APD.
Investigators will compare the f-MRI results between three groups of children in order to find specific radiological markers of APD :
The study will include a multidisciplinary consultation with:
The purpose of the study is looking for objective biomarkers of APD:
With this multidisciplinary evaluation, the investigators wish to improve the diagnosis of APD in suspected children by associating clinical, radiological, electro-physiological and genetic criteria.
Better understanding and more accurate diagnosis of APD's will improve the care management of these children.
24 studies on the registry are indexed under Auditory Perceptual Disorders; 3 are open to participants now.
This study's enrollment of 45 is below the median of 52 across 18 interventional studies indexed under Auditory Perceptual Disorders.
Browse Auditory Perceptual Disorders studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,592 studies on the registry; 1,033 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Inclusion Criteria Group 1 \& 2: :
Inclusion Criteria Group 3:
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic
Diagnostic Test: functional MRI · Diagnostic Test: Automated Cortical Brainstem Auditory Evoked Potential · Genetic: whole exome sequencing
functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic
Diagnostic Test: functional MRI · Diagnostic Test: Automated Cortical Brainstem Auditory Evoked Potential
functional MRI, Cortical Brainstem Auditory Evoked Potential, Genetic, multidisciplinary consultation
Diagnostic Test: functional MRI · Diagnostic Test: Automated Cortical Brainstem Auditory Evoked Potential · Diagnostic Test: Standard Cortical Brainstem Auditory Evoked Potential · Diagnostic Test: multidisciplinary consultation
Additional sequence (DTI) and functional MRI (fMRI) during the MRI which is done as part of the usual care
Automated Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
A study of all the DNA-encoding exons of the child/parent from a sample taken as part of the usual care
Standard Cortical Brainstem Auditory Evoked Potential correspond to a non-invasive EEG
multidisciplinary consultation is composed of: * an ENT consultation and audiometry * a speech therapy assessment * a psychometric evaluation
BOLD effect
BOLD effect is measured during fMRI and compared between the 3 groups of patients
Time frame: up to 4 weeks
set disyllabic words (Fournier or Boorsma lists)
Speech evaluation : set disyllabic words using the Fournier or Boorsma lists (the French equivalent of the. Peabody PBK test), depending on age
Time frame: up to 4 weeks
RapDys
Speech evaluation
Time frame: up to 4 weeks
Random Gap Detection Test (RGDT)
Speech evaluation
Time frame: up to 4 weeks
Dichotic listening test
Speech evaluation
Time frame: up to 4 weeks
temporal pattern recognition test
Speech evaluation
Time frame: up to 4 weeks
Test of Everyday Attention for Children (TEA-Ch test)
Psychometric evaluation for children aged 7-12 years
Time frame: up to 4 weeks
Wechsler Intelligence Scale for Children (WISC-V) test
Psychometric evaluation for children aged 13-18 years
Time frame: up to 4 weeks
Chromosomal analysis (group 1 only)
Genetic analysis
Time frame: up to 12 months
Work Environment Scale (WES) sequencing (group 1 only)
Genetic analysis
Time frame: up to 12 months
Measures of P1, N1, P2, N2 waves' Latencies
Cortical Brainstem Auditory Evoked
Time frame: At inclusion day (visit 1) and at 12 months (group 1 and 2 only)
Measures of P1, N1, P2, N2 waves' amplitudes
Cortical Brainstem Auditory Evoked
Time frame: At inclusion day (visit 1) and at 12 months (group 1 an 2 only)
Infusion Rate (MRI-ASL)
Infusion Rate (MRI-ASL) is measured during MRI
Time frame: up to 4 weeks
tractography results (DTI sequence)
tractography results (DTI sequence) is measured during MRI
Time frame: up to 4 weeks
Plan to share: No
This study is completed, as verified in Mar 2026. You cannot join it, but the record below documents what was studied.
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