An interventional study of Aerobic exercise and Stretching in Mild Cognitive Impairment, sponsored by University of Delaware. Completed at 1 site in United States. Open to participants aged 60 Years to 90 Years. Per ClinicalTrials.gov, last updated 2024-05-14.
Sponsored by University of Delaware · Not applicable, Interventional, and Basic science
This study will measure brain structure through its mechanical properties, assessed with magnetic resonance elastography, and determine whether it improves with aerobic exercise in older adults with low memory abilities. Additionally, this study will determine if memory abilities improve with exercise and if they are related to brain structure. Overall, this project has the potential to identify how brain health is impacted by exercise in older adults.
Mechanical properties of the human brain, measured with magnetic resonance elastography (MRE), reflect the health of brain tissue. Our previous research has shown that these mechanical properties of the hippocampus are highly sensitive to memory function in young adults. Based on these findings, we believe that these mechanical properties may be strong indicators of memory health in older adults and populations experiencing decline in memory function (i.e. mild cognitive impairment, MCI). Further, our results indicate these properties and associated functions are positively impacted by fitness and exercise training, thus making them potentially ideal markers for brain health in assessing rehabilitation.
The objective of this research is to examine these properties in older adults with and without MCI. We will do the following: (1) determine if there are differences in mechanical properties of memory systems in older adults with and without MCI; (2) establish structure-function relationships between mechanical properties and memory performance in the older adult population; and (3) determine if both mechanical properties and memory performance are impacted by cardiovascular health, both through cross-sectional assessment of aerobic fitness and longitudinal response to exercise training.
3,842 studies on the registry are indexed under Cognitive Dysfunction; 1,099 are open to participants now.
This study's enrollment of 36 is below the median of 65 across 2,807 interventional studies indexed under Cognitive Dysfunction.
Browse Cognitive Dysfunction studies →University of Delaware is the lead sponsor of 125 studies on the registry; 23 are open to participants now.
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Exclusion Criteria:
Exercise training
Behavioral: Aerobic exercise
Control
Behavioral: Stretching
Participants will complete 12 weeks of supervised aerobic exercise, 3 times per week, on a treadmill or stationary bicycle
Participants will complete 12 weeks of supervised stretching, 3 times per week
Change in brain mechanical properties
Investigators are assessing change in brain structure through mechanical properties in response to exercise from baseline to the end of the 12 week program. An MRI scan with magnetic resonance elastography (MRE) will be used to measure properties of brain regions important to memory (e.g. hippocampus).
Time frame: Baseline, 12 weeks
Change in relational memory performance
Behavioral memory test will be used to assess relational memory through accuracy on a spatial reconstruction task.
Time frame: Baseline, 12 weeks
Change in cardiorespiratory fitness
Graded exercise test will measure cardiorespiratory fitness through volume of oxygen uptake (VO2)
Time frame: Baseline, 12 weeks
Change in brain morphometry
MRI will be used to measure brain morphometry, i.e. volume
Time frame: Baseline, 12 weeks
Change in brain function
MRI will be used to measure brain function, i.e. functional connectivity
Time frame: Baseline, 12 weeks
Change in brain white matter integrity
Diffusion MRI will be used to measure integrity of white matter tracts
Time frame: Baseline, 12 weeks
Change in cognitive function
NIH Toolbox will be used to assess cognitive function across several domains
Time frame: Baseline, 12 weeks
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in May 2024. You cannot join it, but the record below documents what was studied.
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University of Delaware