An observational study in Drug Reaction, Anesthetic and Hemodynamic Rebound, sponsored by Xiangya Hospital of Central South University. Completed at 1 site in China. Open to participants aged 20 Years to 75 Years. Per ClinicalTrials.gov, last updated 2022-03-02.
Sponsored by Xiangya Hospital of Central South University · Observational
This study intends to study the effects of anesthetics on Circulatory Function Genomics and find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target DNA level differences, further guiding individual treatment in clinic, promoting the development of precision the medicine.The anesthesia medication during perioperative period is more and more accurate,reasonable and safe, so as to improve the satisfaction of the patients and their families in the perioperative period, to ensure the safety of patients.
This study is a non traumatic and non intervention study, and will use a large sample of clinical research, the number of subjects to be enrolled in the study group are 200 cases. The basic information of the study was included in the study before the operation. During the operation, the investigators need a collection of participants's arterial blood and monitor the hemodynamic index and anesthesia depth by bispectral index(BIS) . Further more，the investigators will follow up the participants' condition after operation.Dividing the patients into different groups according to their clinical features.The relationship between vital signs and the depth of anesthesia was analyzed and compared between different groups.Blood samples collected during the operation were detected by gene test. Comparing the results of genetic testing and clinical data analysis, then the investigators will find the differences in the expression of the gene polymorphisms of anesthetic drugs in the circulating function.
437 studies on the registry are indexed under Drug-Related Side Effects and Adverse Reactions; 76 are open to participants now.
This study's enrollment of 223 is below the median of 330 across 159 observational studies indexed under Drug-Related Side Effects and Adverse Reactions.
Browse Drug-Related Side Effects and Adverse Reactions studies →Xiangya Hospital of Central South University is the lead sponsor of 170 studies on the registry; 76 are open to participants now.
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Patients from department of thoracic and cardiovascular surgery in Xiangya Hospital, Central South University
Exclusion Criteria:
Genotyping results of anesthetic drugs
Genotype information of SNP related to anesthetic drug metabolism, such as AA, AG or GG
Time frame: one year
vital signs
The percentage of change in mean arterial pressure and heart rate
Time frame: one year
depth of anesthesia
The value of BIS
Time frame: one year
prognostic indicator
The days of patients' hospital stay time
Time frame: one year
Plan to share: No
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This study is completed, as verified in Mar 2018. You cannot join it, but the record below documents what was studied.
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Drug-Related Side Effects and Adverse Reactions→
Xiangya Hospital of Central South University