An interventional study of Activity/Moderate Exercise in Sedentary Lifestyle, Insulin Sensitivity and Glucose Metabolism, sponsored by University of Prince Edward Island. Terminated at 1 site in Canada. Open to participants aged 18 Years to 50 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-01-29.
Sponsored by University of Prince Edward Island · Not applicable, Interventional, and Prevention
Individuals with pre-diabetes or diabetes would benefit from low impact methods that would improve their insulin sensitivity and aid in maintaining glucose homeostasis. Physical activity helps the body decrease its insulin resistance and burn excess sugar. Many diabetics also suffer from obesity and specific forms or durations of physical exercise may not be viable options for these individuals. Determining whether short bursts of moderate exercise improve blood glucose levels in healthy humans may identify a further method for diabetics to improve their glucose homeostasis.
The aim of this study is to determine the most effective moderate exercise that can be completed in 3 minutes and its effectiveness on improving glucose handling, in response to a single day of standardized high-fat and high-carbohydrate feeding in comparison to periods of prolonged sitting.
1,273 studies on the registry are indexed under Sedentary Behavior; 300 are open to participants now.
This study's enrollment of 6 is below the median of 60 across 1,076 interventional studies indexed under Sedentary Behavior.
Browse Sedentary Behavior studies →University of Prince Edward Island is the lead sponsor of 13 studies on the registry; 1 is open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
No intervention. Study participants will be seated during the entire sedentary 3-hour time period and wheeled to phlebotomy (and exercise) stations when required. During the sedentary period, participants will eat the food according to the study protocol and be seated at desks and allowed to read and use computers.
Will disrupt their sedentary time with 3 minute exercise sessions every 30 minutes
Other: Activity/Moderate Exercise
3-hour sedentary period with 3 minute activity breaks of moderate exercise every 30 minutes
Change in Insulin levels
The change in blood insulin levels from baseline (12 hours fasted) to 3-hours post-prandial will be determined from blood serum using a human metabolic hormone multiplex panel (Luminex xMAP technology).
Time frame: Pre-prandial baseline (12 hours fasted) and 3 hours post-prandial on each of two testing days
Change in concentration of C-peptide
The change in blood C-peptide levels from baseline (12 hours fasted) to 3-hours post-prandial will be determined from blood serum using a human metabolic hormone multiplex panel (Luminex xMAP technology).
Time frame: Pre-prandial baseline (12 hours fasted) and 3 hours post-prandial on each of two testing days
Changes in blood glucose levels
Blood glucose levels will be determined at pre-prandial baseline and over the following 3-hour testing period using hand-held blood glucose meters.
Time frame: Baseline and every 30-60 minutes over 3 hours (6 timepoints per test day)
Change in metabolomic response to a test meal
Targeted metabolomics analysis of approximately 139 metabolites in blood serum by LC-MS/MS to generate a metabolomic profile in response to a high-fat and high-carbohydrate test meal. Metabolites to be determined are categorized as biogenic amines, amino acids, histidines, carboxylic acids, acylcarnitines, glycerophospholipids and organic acids.
Time frame: Pre-prandial and 3-hours post test meal through study completion
Immediate effects of short-term sedentary behaviour on cognitive function
Assessing cognitive abilities using the Stroop Test.
Time frame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
Immediate effects of short-term sedentary behaviour on cognitive function
Assessing cognitive abilities using the Iowa Trail Making Test.
Time frame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
Immediate effects of short-term sedentary behaviour on cognitive function
Assessing cognitive abilities using the Digit-Span test.
Time frame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
Immediate effects of short-term sedentary behaviour on cognitive function
Assessing cognitive abilities using the N-back test.
Time frame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
Immediate effects of short-term sedentary behaviour on cognitive function
Assessing cognitive abilities using the Flankers test.
Time frame: 3 hours post-activity (sedentary behaviour or exercise) on test days through study completion
Gene expression levels in isolated PBMC populations
Determining changes in gene expression in pathways associated with RAGE signalling.
Time frame: Pre-prandial and 3 hours post-prandial on on test days through study completion
Ran from Jan 2019 to primary completion in Oct 2019, 9 months.
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This study is terminated, as verified in Jan 2019. You cannot join it, but the record below documents what was studied.
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University of Prince Edward Island