An interventional study of Exercise Training in Methods of Exercise in Children, sponsored by University of California, Irvine. Completed at 1 site in United States. Open to participants aged 7 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-03-23.
Sponsored by University of California, Irvine · Not applicable, Interventional, and Basic science
The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs.Participants will exercise in different protocols on a bicycle ergometer or treadmill. This research could lead to improved and more accurate fitness assessment and pave the way to an improved personalized exercise program in health and illness.
The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs. For example, some people like to exercise continuously for relatively long periods of time while others like to exercise for short periods of time with rest periods in between. Children tend to exercise in frequent bouts of brief exercise interspersed with periods of rest. Also, some people like running or treadmill exercise while others like to work out on stationary bicycles. To date, standard exercise testing is based on a century-old paradigm used predominantly for adults that involves maximal exercise protocols (cardiopulmonary exercise testing-CPET). Moreover, different but widely used exercise modalities such as cycle ergometer and treadmills are currently impossible to compare in children, and this has limited the clinical and research application of such testing in the pediatric age-range. A major premise of this laboratory is that laboratory testing of cardiopulmonary fitness in children should be based on protocols that mimic naturally occurring patterns of exercise in children, rather than those that have been artificially employed to assess maximal efforts in adults. This research project designed to begin the process of systematically identifying protocols can be best used for children and young adults. Participants will exercise in different protocols on a bicycle ergometer or treadmill. This research could lead to improved and more accurate fitness assessment and pave the way to an improved personalized exercise program in health and illness.
University of California, Irvine is the lead sponsor of 466 studies on the registry; 96 are open to participants now.
Of its 41 completed or terminated interventional studies of FDA-regulated products, 30 (73%) have results posted.
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Exclusion Criteria:
Comparison of gas exchange kinetics and heart rate in cyclo ergometer exercises among children
Other: Exercise Training
Comparison of gas exchange kinetics and heart rate in treadmill exercises among children
Other: Exercise Training
Comparison of gas exchange kinetics and heart rate in cyclo ergometer exercises among adolescents
Other: Exercise Training
Comparison of gas exchange kinetics and heart rate in treadmill exercises among adolescents
Other: Exercise Training
Comparison of gas exchange kinetics and heart rate in cyclo ergometer exercises among adults
Other: Exercise Training
Comparison of gas exchange kinetics and heart rate in treadmill exercises among adults
Other: Exercise Training
Comparison of stationary bike and treadmill exercise among children, adolescents and adults
Maximum Oxygen Uptake (VO2) Measurements During Exercise
Breath by breath gas exchange VO2 in response to exercise.
Time frame: At least 48 hours
Heart Rate (HR) Measurements During Exercise
Heart Rate (HR) values in response to exercise
Time frame: At least 48 hours
| Milestone | Treadmill and Cyclo Ergometer Exercise in Children | Treadmill and Cyclo Ergometer Exercise in Adolescents | Treadmill and Cyclo Ergometer Exercise in Adults |
|---|---|---|---|
| Started | 34 | 41 | 19 |
| Completed | 34 | 41 | 19 |
| Not completed | 0 | 0 | 0 |
Breath by breath gas exchange VO2 in response to exercise.
| L/min | Cyclo Ergometer andTreadmill Exercise in Children | Cyclo Ergometer and Treadmill Exercise in Adolescents | Cyclo Ergometer and Treadmill Exercise in Adults |
|---|---|---|---|
| Cyclo Ergometer Peak VO2 (L/min) | 1.6 ± 0.4 | 2.8 ± 0.6 | 3.2 ± 0.8 |
| Treadmill Peak V02 (L/min) | 1.7 ± 0.4 | 2.9 ± 0.5 | 3.5 ± 0.5 |
Heart Rate (HR) values in response to exercise
| beat/min | Cyclo Ergometer and Treadmill Exercise in Children | Cyclo Ergometer and Treadmill Exercise in Adolescents | Cyclo Ergometer and Treadmill Exercise in Adults |
|---|---|---|---|
| Cyclo Ergometer Peak HR (beat/min) | 197.2 ± 8.8 | 195.5 ± 9.8 | 186.6 ± 9.9 |
| Treadmill Peak HR (beat/min) | 194.6 ± 8.4 | 198.1 ± 8.1 | 190.4 ± 10.7 |
Collected over During the 30 min exercise for each of the two sessions.. Non-serious events are listed at a 0% frequency threshold.
| Group | Deaths | Serious | Other |
|---|---|---|---|
| Cycle Ergometer Exercise in Children | 0/34 (0%) | 0/34 (0%) | 0/34 (0%) |
| Treadmill Exercise in Children | 0/41 (0%) | 0/41 (0%) | 0/41 (0%) |
| Cycle Ergometer Exercise in Adolescents | 0/19 (0%) | 0/19 (0%) | 0/19 (0%) |
| Treadmill Exercise in Adolescents | 0/34 (0%) | 0/34 (0%) | 0/34 (0%) |
| Cycle Ergometer Exercise in Adults | 0/41 (0%) | 0/41 (0%) | 0/41 (0%) |
| Treadmill Exercise in Adults | 0/19 (0%) | 0/19 (0%) | 0/19 (0%) |
| Age, Categorical(Participants) | Treadmill and Cycle Ergometer Exercise in Children | Treadmill and Cycle Ergometer Exercise in Adolescents | Treadmill and Cycle Ergometer Exercise in Adults | Total |
|---|---|---|---|---|
| <=18 years | 34 | 41 | 0 | 75 |
| Between 18 and 65 years | 0 | 0 | 19 | 19 |
| >=65 years | 0 | 0 | 0 | 0 |
| Age, Continuous(years) | Treadmill and Cycle Ergometer Exercise in Children | Treadmill and Cycle Ergometer Exercise in Adolescents | Treadmill and Cycle Ergometer Exercise in Adults | Total |
|---|---|---|---|---|
| Mean | 9.8 ± 1.4 | 16.2 ± 1.6 | 27.7 ± 3.5 | 17.9 ± 2.1 |
| Sex: Female, Male(Participants) | Treadmill and Cycle Ergometer Exercise in Children | Treadmill and Cycle Ergometer Exercise in Adolescents | Treadmill and Cycle Ergometer Exercise in Adults | Total |
|---|---|---|---|---|
| Female | 16 | 23 | 11 | 50 |
| Male | 18 | 18 | 8 | 44 |
| Race/Ethnicity, Customized(Participants) | Treadmill and Cycle Ergometer Exercise in Children | Treadmill and Cycle Ergometer Exercise in Adolescents | Treadmill and Cycle Ergometer Exercise in Adults | Total |
|---|---|---|---|---|
| Ethnicity (Hispanic/Latino) | 1 | 3 | 0 | 4 |
| Race (White) | 29 | 24 | 12 | 65 |
| Race (Asian) | 3 | 17 | 6 | 26 |
| Race (African-American) | 2 | 0 | 1 | 3 |
| Region of Enrollment(participants) | Treadmill and Cycle Ergometer Exercise in Children | Treadmill and Cycle Ergometer Exercise in Adolescents | Treadmill and Cycle Ergometer Exercise in Adults | Total |
|---|---|---|---|---|
| United States | 34 | 41 | 19 | 94 |
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University of California, Irvine