CClinicalTrials.gg
Status unknownNCT03762538Updated Dec 3, 2018

The Effect of the ALDH2 Gene Polymorphism on the Propofol Potency for Inducing Loss of Consciousness

An observational study in Propofol, sponsored by Shanghai Zhongshan Hospital. Status unknown. Open to male participants aged 50 Years to 75 Years. Per ClinicalTrials.gov, last updated 2018-12-03.

Sponsored by Shanghai Zhongshan Hospital · Observational

The sponsor has not verified this record recently (last verified Jan 2018), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
100
Ages
50 Years to 75 Years
Sex
Male
01

Study summary

The aim of this study is to determine whether ALDH2 gene polymorphisms (G/G, G/A A/A) have effect on the potency of propofol.

02

Conditions studied

  • Propofol

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Keywords

  • propofol
  • ALDH2
  • potency
03

In context

Unconsciousness

89 studies on the registry are indexed under Unconsciousness; 11 are open to participants now.

This study's planned enrollment of 100 is above the median of 80 across 30 observational studies indexed under Unconsciousness.

Browse Unconsciousness studies →

Lead sponsor

Shanghai Zhongshan Hospital is the lead sponsor of 636 studies on the registry; 283 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years to 75 Years
Sexes eligible
Male
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

operation rooms for cardiac surgeries in our institution(a major hospital in China)

Inclusion criteria

  • ASA II

Exclusion criteria

Exclusion Criteria:

  • ASA III-IV
  • OSAS
  • hepatic and renal insufficiency
05

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No

Groups and cohorts

  • G/G group

    Patients who are determined to be G/G genotype.

    Drug: Propofol

  • G/A A/A group

    Patients who are determined to be G/A or A/A genotypes.

    Drug: Propofol

Interventions

  • DrugPropofol

    Patients will be induced to unconsciousness using propofol intravenously.

06

What researchers measure

Primary outcomes

  1. Effect-site concentration

    patient's effect-site concentration when he/she loss consciousness

    Time frame: immediately after patient lose his/her consciousness

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 3, 2018, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT03762538
Lead sponsor
Shanghai Zhongshan Hospital
Responsible party
Sponsor
First posted
Dec 3, 2018
Start date
Feb 1, 2019 (estimated)
Primary completion
Jun 30, 2019 (estimated)
Completion
Dec 31, 2019 (estimated)
Last update
Dec 3, 2018

Study contacts

Kefang Guo, MD
Contact
drguokefang@foxmail.com
+86-13817706936

Oversight

FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.

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