An interventional study of ferrous fumarate and ferrous sulphate in Iron-deficiency, sponsored by Isabelle Herter-Aeberli. Completed at 1 site in Switzerland. Open to female participants aged 18 Years to 45 Years. Per ClinicalTrials.gov, last updated 2019-07-25.
Sponsored by Isabelle Herter-Aeberli · Not applicable, Interventional, and Prevention
Iron deficiency is still the most common and widespread nutritional disorder in the world according to WHO.
In a recent iron absorption study in adult women with low iron stores in our lab (publication under review), we found that 15 g of GOS given with an iron supplement in the form of iron fumarate acutely increased iron absorption when given with water and a bread based meal. The dose of 15 g of GOS was tolerated well by the participants. As a follow up to the study mentioned above, we want to investigate: 1) if acute iron absorption is affected by lower doses of GOS; 2) whether this acute effect occurs for other commonly used iron compounds as well, such as iron sulphate and iron phosphate; and 3) if there are potential interactions on absorption with other enhancers of iron absorption, such as vitamin c.
Iron is an important mineral in our body and fulfills essential functions such as for example oxygen transport from the lungs to the tissues. Iron deficiency is still the most common and widespread nutritional disorder in the world according to WHO. Common iron supplements all have their limitations in terms of availability and compatibility. Prebiotic fibers, such as galacto-oligosaccharides (GOS), selectively enhance growth of beneficial colonic bacteria. Prebiotics in general enhance the production of short-chain fatty acids (SCFAs) and thereby decrease luminal pH. Through the reduction in pH, prebiotics can enhance absorption of minerals such as calcium and magnesium and they have been proposed to potentially improve iron absorption.
In a recent iron absorption study in adult women with low iron stores in our lab (publication under review), we found that 15 g of GOS given with an iron supplement in the form of iron fumarate acutely increased iron absorption when given with water and a bread based meal. The dose of 15 g of GOS was tolerated well by the participants. As a follow up to the study mentioned above, we want to investigate: 1) if acute iron absorption is affected by lower doses of GOS; 2) whether this acute effect occurs for other commonly used iron compounds as well, such as iron sulphate and iron phosphate; and 3) if there are potential interactions on absorption with other enhancers of iron absorption, such as vitamin c.
644 studies on the registry are indexed under Anemia, Iron-Deficiency; 105 are open to participants now.
This study's enrollment of 46 is below the median of 100 across 503 interventional studies indexed under Anemia, Iron-Deficiency.
Browse Anemia, Iron-Deficiency studies →Isabelle Herter-Aeberli is the lead sponsor of 13 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
labelled iron as ferrous fumarate
Dietary Supplement: ferrous fumarate
labelled iron as ferrous sulphate
Dietary Supplement: ferrous sulphate
labelled iron as ferric pyrophosphate
Dietary Supplement: ferric pyrophosphate
labelled iron as ferrous fumarate + prebiotics in the form of 3.5 g GOS
Dietary Supplement: ferrous fumarate + 3.5 g GOS
labelled iron as ferrous fumarate + prebiotics in the form of 7 g GOS
Dietary Supplement: ferrous fumarate + 7 g GOS
labelled iron as ferrous sulphate + prebiotics in the form of 15 g GOS
Dietary Supplement: ferrous sulphate + 15 g GOS
labelled iron as ferrous fumarate + Vitamin C
Dietary Supplement: ferrous fumarate + Vitamin C
labelled iron as ferric pyrophosphate + prebiotics in the form of 15 g GOS
Dietary Supplement: ferric pyrophosphate + 15 g GOS
labelled iron as ferrous fumarate + prebiotics in the form of 7 g GOS + Vitamin C
Dietary Supplement: ferrous fumarate + 7 g GOS + Vitamin C
nutritional iron (14 mg) supplement in form of ferrous fumarate
nutritional iron (14 mg) supplement in form of ferrous sulphate
nutritional iron (14 mg) supplement in form of ferric pyrophosphate
nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of prebiotics (3.5 g GOS)
nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of prebiotics (7 g GOS)
nutritional iron (14 mg) supplement in form of ferrous sulphate with addition of prebiotics (15 g GOS)
nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of Vitamin C
nutritional iron (14 mg) supplement in form of ferric pyrophosphate with addition of prebiotics (15 g GOS)
nutritional iron (14 mg) supplement in form of ferrous fumarate with addition of prebiotics (7 g GOS) and Vitamin C
fractional iron absorption
Fractional iron absorption will be calculated based on the shift of the iron isotope ratios in the collected blood samples after the administration of several isotopically labelled iron supplements.Fractional iron absorption will be measured as erythrocyte incorporation of the naturally occurring iron forms with different masses used to label the iron supplements.
Time frame: 2 months
Plan to share: No
This study is completed, as verified in Jul 2019. You cannot join it, but the record below documents what was studied.
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Isabelle Herter-Aeberli