An observational study in Autism Spectrum Disorder, sponsored by University Hospital, Tours. Completed at 2 sites in France. Open to participants aged 3 Years to 12 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-05-25.
Sponsored by University Hospital, Tours · Observational
Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation. Currently, the diagnosis of Autism Spectrum Disorder is based on a clinical examination that is performed classically during the first three years of life. The heterogeneity of the disorders occurring in autism make pathologies difficult to diagnose and manage.
The overall goal of this project is the identification of metabolic biomarkers based on clinical profile. The best characterization of physiopathological pathways will ultimately allow the identification of subgroups of subjects and facilitate the development of targeted therapeutics.
The proposed work aims to test the hypothesis of a disruption of tryptophan metabolism in Autism Spectrum Disorder via the gut microbiota.
Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation. In France, Autism Spectrum Disorderaffects about 1 in 100 people according to international criteria and is diagnosed in early childhood. Currently, the diagnosis of Autism Spectrum Disorder is based on a clinical examination that is performed classically during the first three years of life. The heterogeneity of the disorders occurring in autism make pathologies difficult to diagnose and manage.
The overall goal of this project is the identification of metabolic biomarkers based on clinical profile (based on behavioral and cognitive markers). The best characterization of physiopathological pathways (from the molecular scale to the phenotypic scale) will ultimately allow the identification of subgroups of subjects and facilitate the development of targeted therapeutics.
The proposed work aims to test the hypothesis of a disruption of tryptophan metabolism in Autism Spectrum Disorder via the gut microbiota.
1,344 studies on the registry are indexed under Autistic Disorder; 334 are open to participants now.
This study's enrollment of 66 is below the median of 102 across 267 observational studies indexed under Autistic Disorder.
Browse Autistic Disorder studies →University Hospital, Tours is the lead sponsor of 304 studies on the registry; 78 are open to participants now.
Counted across the registry records on this site, refreshed daily.
3-12 year old children with and without Autism Spectrum Disorders
Inclusion Criteria (patient):
Exclusion Criteria (patient):
Inclusion Criteria (healthy volunteer):
Exclusion Criteria (healthy volunteer):
Taken biological samples on patients with Autism Spectre Disorders
Other: Samples
Taken biological samples on patients healthy volunteers
Other: Samples
Urinary and faecal samples
Urinary concentrations of tryptophan metabolites
Quantification by High-Performance Liquid Chromatography and Mass Spectrometry
Time frame: At baseline
Faecal concentrations of tryptophan metabolites
Quantification by using High-Performance Liquid Chromatography and Mass Spectrometry
Time frame: At baseline
Characterization of gut microbiota
Characterization by 16S ribosomal RNA sequencing
Time frame: At baseline
Correlation of metabolic profiles of tryptophan and microbiotic profiles
Study of correlations from the outcomes measures 1, 2 and 3
Time frame: At baseline
This study is completed, as verified in May 2022. You cannot join it, but the record below documents what was studied.
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University Hospital, Tours