An interventional study of Low Load Resistance Exercise and Low Load Resistance Exercise + BFR in Mitochondria, Strength and Hypertrophy, sponsored by Louisiana State University and A&M College. Completed at 1 site in United States. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-08-16.
Sponsored by Louisiana State University and A&M College · Not applicable, Interventional, and Basic science
Blood flow restricted (BFR) exercise has been shown to improve skeletal muscle adaptations to resistance exercise. BFR uses blood pressure cuffs (i.e., tourniquets) to reduce skeletal muscle blood flow during resistance exercise. One benefit of BFR is that skeletal muscle adaptations to resistance exercise training including muscle hypertrophy and increases in strength can be achieved at lower-loads (e.g., 25-30% 1RM), that are often comparable to more traditional resistance training loads (70-85% 1RM). However, the impact that low-load BFR resistance exercise has on muscle quality and bioenergetics is unknown. The present study will examine the impact of 6 weeks of low-load, single-leg resistance exercise training with or without personalized BFR on measures of muscle mass, strength, quality, and mitochondrial bioenergetics. The investigators will recruit and study up to 30, previously sedentary, healthy, college-aged adults (18-40 years). The investigators will measure muscle mass using Dual Energy X-Ray Absorptiometry and muscle strength and endurance using isokinetic testing. The investigators will normalize knee extensor strength to lower limb lean mass to quantify muscle quality. The investigators will also use near infrared spectroscopy (NIRS) to measure mitochondrial oxidative capacity in the vastus lateralis. Finally, the investigators will measure markers of systemic inflammation and markers of muscle damage using commercially available ELISA assays.
656 studies on the registry are indexed under Hypertrophy; 87 are open to participants now.
This study's enrollment of 24 is below the median of 50 across 460 interventional studies indexed under Hypertrophy.
Browse Hypertrophy studies →Louisiana State University and A&M College is the lead sponsor of 13 studies on the registry; 7 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria.
Absolute Contraindication to Exercise as Defined by the American College of Sports Medicine,1 including:
Subjects allocated to Low Load Resistance Exercise will undergo 6 weeks of single-legged low load (25%) resistance exercise. Their contralateral leg will serve as within subject control.
Behavioral: Low Load Resistance Exercise
Subjects allocated to Low Load Resistance Exercise + BFR will undergo 6 weeks of single-legged low load (25%) resistance exercise plus blood flow restriction. Their contralateral leg will serve as within subject control.
Behavioral: Low Load Resistance Exercise + BFR
Subjects allocated to Low Load Resistance Exercise will undergo 6 weeks of single-legged low load (25%) resistance exercise. Subjects will then perform 4 sets of 30, 15, 15 and 15 repetitions at 25% of their 1RM for the single-legged leg press and single-legged knee extensions. Their contralateral leg will serve as within subject control.
Subjects allocated to Low Load Resistance Exercise + BFR will undergo 6 weeks of single-legged low load (25%) resistance exercise with blood flow restriction (60% occlusion pressure). Subjects will then perform 4 sets of 30, 15, 15 and 15 repetitions at 25% of their 1RM for the single-legged leg press and single-legged knee extensions. Their contralateral leg will serve as within subject control.
Changes in Mitochondrial Oxidative Capacity
Changes in mitochondrial oxidative capacity will be measured using near infrared spectroscopy (NIRS).
Time frame: Changes from baseline (pre-training) to follow-up (about 48-72 hours post-training).
Changes in Muscle Mass measured by Dual Energy X-ray Absorptiometry
Changes in muscle mass will be measured by Dual Energy X-ray Absorptiometry
Time frame: Changes from baseline (pre-training) to follow-up (about 48-72 hours post-training)
Changes in Muscle Strength measured using Isokinetic Dynamometry
Changes in muscle strength measured using isokinetic dynamometry
Time frame: Changes from baseline (pre-training) to follow-up (about 48-72 hours post-training)
Changes in Muscle Endurance measured using Isokinetic Dynamometry
Changes in muscle endurance measured using isokinetic dynamometry
Time frame: Changes from baseline (pre-training) to follow-up (about 48-72 hours post-training)
This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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Louisiana State University and A&M College