An interventional study of Exercise Training in Asthma in Children, sponsored by University of California, Irvine. Withdrawn at 1 site in United States. Open to participants aged 8 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-02-12.
Sponsored by University of California, Irvine · Not applicable, Interventional, and Prevention
The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma
3,921 studies on the registry are indexed under Asthma; 507 are open to participants now.
Browse Asthma studies →University of California, Irvine is the lead sponsor of 466 studies on the registry; 96 are open to participants now.
Of its 41 completed or terminated interventional studies of FDA-regulated products, 30 (73%) have results posted.
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Exclusion Criteria:
Healthy control group which received the same exercise training intervention as the experimental group
Other: Exercise Training
Subjects with asthma who received exercise training
Other: Exercise Training
Physical activity in children and adults with asthma.
Gene and microRNA expression will be compared between healthy and asthmatic subjects
Monocyte gene expression profiling before and after acute bout of exercise before and after 10-week exercise intervention is gauged using RNA seq in a group of children with asthma and age and sex match healthy controls
Time frame: 12 weeks
Pro/anti-inflammatory cytokines and markers of oxidative stress will be compared between the groups
Absolute values of cytokines, growth hormones, and other biomarkers will be measured by flow cytometry and statistically analyzed.
Time frame: 12 weeks
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This study is withdrawn, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.
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University of California, Irvine