An observational study in Syphilis, sponsored by London School of Hygiene and Tropical Medicine. Completed at 5 sites in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-04-12.
Sponsored by London School of Hygiene and Tropical Medicine · Observational
Syphilis is an important sexually transmitted infection. There has been an epidemic of syphilis amongst men who have sex with men in the United Kingdom in the last decade. Early infection with syphilis causes a genital ulcer followed, in the absence of treatment, by a generalised illness often accompanied by rash. Studies on syphilis have been limited because it is not possible to grow syphilis outside of the body. New approaches allow the whole genetic sequence of Treponema pallidum to be obtained from a swab.
In this study residual DNA collected as part of routine patient care of patients seen at sexual health clinics in the UK will be used for sequencing. No patient contact is involved in the study which is limited to whole genome sequencing using residual material from samples. By better understanding the genome of the T.pallidum insights will be gained in to the pathogenesis of this important sexually transmitted disease.
120 studies on the registry are indexed under Syphilis; 33 are open to participants now.
This study's enrollment of 726 is above the median of 356 across 36 observational studies indexed under Syphilis.
Browse Syphilis studies →London School of Hygiene and Tropical Medicine is the lead sponsor of 296 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients presenting to sexual health services in UK with a diagnosis of syphilis.
We will identify residual T.pallidum DNA from routinely collected clinical samples held at participating clinics/hospitals. Data accompanying these samples will be anonymised and will not include patient identifiable information. Accompanying data will include: city of origin, age, gender, HIV status and sexual orientation.
Exclusion Criteria:
Patients with syphilis and detectable Treponema pallidum DNA in a routinely collected clinical sample
Diagnostic Test: Whole Genome Sequencing
Residual DNA from clinical samples will be utilised for whole genome sequencing of Treponema pallidum the causative agent of syphilis
Genomic Diversity of Treponema Pallidum as assessed by nucleotide diversity and phylogenetic lineage
Whole genome sequencing of UK and global syphilis samples combined with phylogenomic and population genomic analyses to determine the population structure and diversity of Treponema both regionally and in global context. Diversity will be assessed by measuring nucleotide diversity between samples and reference genomes.
Time frame: Measured at baseline - time of enrollment. There are no further samples or visits in the study.
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Apr 2022. You cannot join it, but the record below documents what was studied.
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London School of Hygiene and Tropical Medicine