An interventional study of fractional curettage in Abnormal Uterine Bleeding, sponsored by Department of Medical Services Ministry of Public Health of Thailand. Completed at 1 site in Thailand. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2024-12-03.
Sponsored by Department of Medical Services Ministry of Public Health of Thailand · Not applicable, Interventional, and Treatment
Comparison of the efficiency of oral Etoricoxib versus intravenous Fentanyl on post operative Pain in curettage under TIVA: A randomized controlled trial
Fractional Curettage is the most widely used for diagnostic and treatment abnormal uterine bleeding. The patient categorize post-operative pain as mild to moderate. Therefore, the effective analgesic added on intraoperative and post-operative is the most important factor in patient's satisfaction, patient well co-operation, shortness time of operation, decrease unpleasant symptoms and rapid recovery. However, there are many anesthetic technique that can be used to relive pain in the operation such as local anesthesia, total intravenous anesthesia, regional anesthesia or oral analgesic drugs.
Intravenous Fentanyl is an short acting opioid. It has a fast onset of action within 2 minutes and short duration of action 30-60 minutes. Respiratory depression, hypotension and bradycardia are adverse effects that might delayed discharge especially in one day surgery e.g. fractional curettage. Etoricoxib is an oral COX-2 specific inhibitor which can be used to relieve the pain. The onset of analgesia can be occurred within 24 minutes which peak plasma level within 60 minutes. There are many empirical evidences to support the results of post-operative pain after used oral Etoricoxib or intravenous Fentanyl. However, there are less evidences to support efficiency of oral Etoricoxib versus intravenous Fentanyl on post-operative Pain in fractional curettage under TIVA
103 studies on the registry are indexed under Metrorrhagia; 27 are open to participants now.
This study's enrollment of 60 is below the median of 109 across 79 interventional studies indexed under Metrorrhagia.
Browse Metrorrhagia studies →Department of Medical Services Ministry of Public Health of Thailand is the lead sponsor of 39 studies on the registry; 10 are open to participants now.
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Subjects will receive oral Etoricoxib120 mg 30 minutes before fractional curettage then added intravenous Propofol 2 mg/kg when start the procedure
Procedure: fractional curettage
Subjects will receive oral placebo \[folic acid\] 1 tab 30 minutes before the procedure then added intravenous Propofol 2 mg/kg and Intravenous Fentanyl 1 microgram/kg when start the procedure
Procedure: fractional curettage
Fractional curettage under TIVA by used oral Etoricoxib120 mg at 30 minutes before fractional curettage and then added intravenous Propofol 2 mg/kg when start the procedure or Intravenous Fentanyl 1 microgram/kg and Propofol 2 mg/kg when start the procedure
post operative pain
Compare efficacy of oral Etoricoxib and intravenous Fentanyl for post fractional curettage pain by using a visual analog pain scale \[Score 0-10\]
Time frame: at 60 minute after operation
post operative pain
Compare efficacy of oral Etoricoxib and intravenous Fentanyl for post fractional curettage pain by using a visual analog pain scale \[Score 0-10\]
Time frame: at 30 minute after operation
post operative pain
Compare efficacy of oral Etoricoxib and intravenous Fentanyl for post fractional curettage pain by using a visual analog pain scale \[Score 0-10\]
Time frame: at 15 minute after operation
Adverse effect from the drugs during and post operation
Record subject experience of the following symptoms : nausea and vomiting ,dizziness, drowsiness ,allergic reaction ,chest pain ,and gastrointestinal bleeding or gastrointestinal discomfort
Time frame: since subject receive drugs until 60 minutes after procedure
Amount of intravenous Propofol used in the procedure
Record dose of intravenous Propofol that used in TIVA
Time frame: only intraoperative time
The first time pain reliever was used in post operation
Record the first time patient asked for post operative pain reliver or visual analog pain score \> 5
Time frame: within 60 minutes after the procedure
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from Nov 2018 to primary completion in Apr 2019, 5 months.
Of 27 interventional studies with no phase under Metrorrhagia, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 20. This study's 5 months is below that.
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This study is completed, as verified in Oct 2018. You cannot join it, but the record below documents what was studied.
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Department of Medical Services Ministry of Public Health of Thailand