An observational study in Neovascular Age-related Macular Degeneration, sponsored by Hospital Hietzing. Completed. Open to participants aged 66 Years to 98 Years. Per ClinicalTrials.gov, last updated 2018-09-20.
Sponsored by Hospital Hietzing · Observational
Purpose:
To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term follow-up and to evaluate morphological markers potentially influencing prognosis.
Methods:
18 patients (18 eyes) with neovascular AMD were recruited subsequent to completion the Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) study following a mean period of 84 months (range: 69-93 months). After receiving a loading dose of 3 intravitreal anti-VEGF injections subsequent to baseline of the MANTA study, patients were treated as-needed [pro re nata (PRN)]. Functional and morphological changes were assessed using spectral domain optical coherence tomography (SD-OCT).
1,459 studies on the registry are indexed under Macular Degeneration; 238 are open to participants now.
This study's enrollment of 18 is below the median of 110 across 409 observational studies indexed under Macular Degeneration.
Browse Macular Degeneration studies →Hospital Hietzing is the lead sponsor of 15 studies on the registry; none are open to participants now.
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Initially 55 Participants were included in the Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) trial [16]. These patients received a loading dose of 3 intravitreal injections of anti-VEGF and were subsequently treated as-needed [pro re nata (PRN)] [16]. From that study population we recruited for another long term follow up visit. Of these patients 9 (16%) were excluded due to missed visits, another 14 patients (25%) died before the last study visit and 14 former participants (25%) did not approve further study participation.
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Exclusion Criteria:
Patients were recruited, visual acuity and optical coherence tomography Pictures were taken
visual acuity
visual acuity testing was performed
Time frame: 93 months
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Sep 2018. You cannot join it, but the record below documents what was studied.
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Hospital Hietzing