An observational study in REM Sleep Behavior Disorder and Neurodegeneration, sponsored by Chinese University of Hong Kong. Completed at 1 site in Hong Kong. Open to participants aged 40 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2021-08-06.
Sponsored by Chinese University of Hong Kong · Observational
Among 11 studies in REM Sleep Behavior Disorder by Chinese University of Hong Kong — 4 open to participants now, 4 under way, none of them phase 3. REM Sleep Behavior Disorder · Chinese University of Hong Kong.
Among the 11 studies in REM Sleep Behavior Disorder by Chinese University of Hong Kong, this one is the 8th largest by enrollment, is one of 2 that started in 2018, is one of 11 observational ones, and was the 4th registered.
101 studies on the registry are indexed under REM Sleep Behavior Disorder; 45 are open to participants now.
Browse REM Sleep Behavior Disorder studies →4 of the 11 studies in REM Sleep Behavior Disorder by Chinese University of Hong Kong are open now, in 1 country. Recruiting first, the newest first:
Chinese University of Hong Kong · Sites in Hong Kong
Chinese University of Hong Kong · Sites in Hong Kong
Ages 45–65 · Healthy volunteers
Chinese University of Hong Kong · Sites in Hong Kong
Ages 40–65 · Healthy volunteers
Chinese University of Hong Kong · Sites in Hong Kong
Ages 50+ · Healthy volunteers
By country, each count listing its studies:
Of the 32 REM Sleep Behavior Disorder studies recruiting now, 18 (56%) set no upper age limit and 4 (13%) stop at 75 or younger; 4 take children under 18; 17 take healthy volunteers.
This study: 40 Years and older · all sexes · healthy volunteers too.
The full table on the hub →This tab as a report to print or save as PDF → With an account.
11 studies; the count open now beside each. This study's row is marked.
First in 2014; this study’s year is marked. 2 started in 2018.
This study's enrollment of 170 is above the median of 119 across 48 observational studies indexed under REM Sleep Behavior Disorder.
Median enrollment 400 across the 11 observational studies. Of the 4 that completed or were terminated, 0 (0%) have results posted.
This tab as a report to print or save as PDF → With an account.
Chinese University of Hong Kong is the lead sponsor of 1,454 studies on the registry; 474 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
None of the studies under way reaches primary completion within a year.
Among the 11 studies in REM Sleep Behavior Disorder by Chinese University of Hong Kong, from their registry updates:
Nothing recorded among them since 2026-09-25.
This tab as a report to print or save as PDF → With an account.
This study is a prospective study with a mean of 5-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in first-degree relatives (FDRs) of idiopathic REM Sleep Behavior Disorder (RBD) patients and healthy controls.
Idiopathic RBD is implicated as an integral part of progression of α-synucleinopathy neurodegeneration, and patients with idiopathic RBD have increased prevalence of non-motor symptoms (or prodromal markers) closely related to Parkinson's disease(PD). Moreover, the investigator's previous studies have further confirmed the familial aggregation of RBD, and first-degree relatives (FDRs) of RBD patients had more prodromal markers of Parkinson's disease compared with FDRs of healthy controls.
In these regards, current prospective study aims to map the progression and evolution of prodromal markers (including autonomic dysfunction, olfactory loss, color vision impairment, neurocognitive impairment, neuroimaging of dopamine dysfunction, daytime sleepiness and psychiatric disorders), onset of RBD, and neurodegenerative diseases. Finally, other markers, such as physical activity and circadian rhythm and tonic electromyography (EMG) activity level, which have been found to be reliably associated with Parkinson's disease or other neurodegenerative diseases. In this regard, it is also interesting to investigate whether these indicators will additionally predict the progression of prodromal markers of PD.
The participants in this proposed study will be recruited from our on-going family cohort of RBD
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
First-degree relatives of idiopathic RBD patients
First-degree relatives of controls
Changes of the overall probability of prodromal Parkinson's disease in the FDRs of patients with RBD.
Changes of the overall probability of prodromal Parkinson's disease will be calculated based on the Movement Disorder Society (MDS) research criteria for prodromal Parkinson's disease in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
Changes of tonic EMG activity in the FDRs of patients with RBD.
Changes of tonic EMG activity is recorded by v-PSG in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
Changes of physical activity level and circadian in the FDRs of patients with RBD.
Changes of physical activity level and circadian are recorded by one-week actigraphy in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
New incidence of RBD and α-synucleinopathy in the FDRs of patients with RBD.
New incidence of probable RBD, video-polysomnography (v-PSG) confirmed definite RBD and α-synucleinopathies in the FDRs of patients with RBD.
Time frame: Baseline and 5 years
Plan to share: Undecided — Researcher in other sleep centers are also conducting similar study, there may be a plan for further collaboration on sharing the database
No publications or documents are linked to this record.
Ran from Sep 2018 to primary completion in Apr 2020, 19 months.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Aug 2021. You cannot join it, but the record below documents what was studied.
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Chinese University of Hong Kong →