An interventional study of Low nucleotide and High nucleotide in Healthy, sponsored by University of Exeter. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-03-26.
Sponsored by University of Exeter · Not applicable, Interventional, and Basic science
Nucleotides are the building blocks for a variety of molecules, including ATP, which is broken down in the skeletal muscle cells to provide fuel for exercise. Nucleotides can be obtained from the diet, and produced or salvaged by the body. Though nucleotides provide the building blocks for ATP, the sugar ribose has been suggested to be rate limiting for synthesising ATP.
Previous studies have shown a decrease in ATP levels in the muscle after intense exercise, and this is linked to fatigue. Other studies have also reported benefits of nucleotide and/or ribose supplementation on exercise performance. However, any potential link between ATP metabolism and exercise performance has not been explored.
This study will look at the effects of nucleotide and nucleotide-ribose supplementation in fuel utilisation and performance in skeletal muscle during endurance exercise.
University of Exeter is the lead sponsor of 140 studies on the registry; 25 are open to participants now.
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Exclusion Criteria:
2 week supplementation with a low nucleotide mycoprotein drink, with added dextrose
Dietary Supplement: Low nucleotide
2 week supplementation with a high nucleotide mycoprotein drink, with added dextrose
Dietary Supplement: High nucleotide
2 week supplementation with a high nucleotide mycoprotein drink, with added ribose
Dietary Supplement: High nucletide + Ribose
2 week, twice daily, supplementation with a nucleotide-depleted mycoprotein drink, with added dextrose
2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added dextrose
2 week, twice daily, supplementation with a nucleotide-rich mycoprotein drink, with added ribose
Changes in muscle ATP concentrations
Time frame: After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
Changes in muscle glycogen concentrations
Time frame: After each supplementation cycle (day 15 of each cycle): baseline (fasted and before exercise), immediately after glycogen depleting exercise (after exercising for 1:30 - 2 hours), immediately after 15 minute time trial and after 3-hour recovery
Blood lactate concentrations
Time frame: After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise
Blood glucose concentrations
Time frame: After supplementation cycle (day 15): baseline and at 15 minute intervals up 1 hour during glycogen depleting exercise
Serum uric acid concentrations
Time frame: Measured at baseline and of days 6, 8 and 15 of each supplementation cycle
Plan to share: No
No publications or documents are linked to this record.
Ran from Jun 2018 to primary completion in Feb 2020, 19 months.
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This study is completed, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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