CClinicalTrials.gg
CompletedNCT03650322Updated Jul 5, 2023

Effects of Yoga, Strength Training and Aerobic Exercise on Cognition in Adult Cancer Survivors

An interventional study of Yoga and Stretching and Toning in Cancer, Cancer-related Problem/Condition and Exercise, sponsored by University of Illinois at Urbana-Champaign. Completed at 1 site in United States. Open to participants aged 30 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2023-07-05.

Sponsored by University of Illinois at Urbana-Champaign · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
78
Allocation
Randomized
Ages
30 Years to 70 Years
Sex
All
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Study summary

The investigators propose to compare the effects of a 12-week, supervised, site-based group yoga intervention on cognitive function, functional fitness, and well-being in middle-aged cancer survivors. Subjects will be randomly assigned to one of three exercise conditions: a yoga group, an aerobic walking group or a strength training group. All sessions (2-3 times per week) will be led by a trained exercise leader for a total of 150 minutes of exercise each week for the 12-week intervention.

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Conditions studied

  • Cancer
  • Cancer-related Problem/Condition
  • Exercise
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In context

Lead sponsor

University of Illinois at Urbana-Champaign is the lead sponsor of 188 studies on the registry; 29 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
30 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • 30-70 years of age
  • Cancer diagnosis
  • 1 year since last cancer treatment (surgery, chemotherapy, and/or radiation)
  • Not planning to receive treatment during study period
  • Completion of Physical Activity Readiness Questionnaire (PAR-Q)
  • Ambulatory and absence of health conditions that may be exacerbated by yoga, walking, or strength training
  • Physician consent (if deemed necessary)
  • Low-active, i.e. less than 150 minutes/week of moderate to vigorous exercise, no current yoga practice (including within last six months)
  • Intention to remain in the Champaign-Urbana area over the study duration
  • Willingness to be randomly assigned to one of the three groups (yoga, aerobic walking, strength training)
  • Comfortable with reading, writing, and speaking English

Exclusion criteria

Exclusion Criteria:

  • Below 30 or above 70 years of age
  • Cancer diagnosis of the brain
  • Less than 1 year since last treatment (surgery, chemotherapy, and/or radiation) or plans to receive treatment during study
  • Determined ambulatory or 'high risk' based on responses to PAR-Q
  • High-active (exercising more than 150 minutes/week in the last six months)
  • No consent from physician
  • Intent to be away from the Champaign-Urbana area for an extended period of time during the study
  • Inability to communicate effectively in English
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Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
78 participants (actual)

Study arms

  • Experimental
    Yoga Practice

    Participants will be led through a beginner yoga course taught by a certified yoga instructor. Classes will meet twice a week for 75 minutes each for the duration of 12 weeks. Sessions will focus on yoga postures, breathing, and meditative practices and may utilize mats, blocks, belts, and blankets.

    Behavioral: Yoga

  • Active comparator
    Stretching and Toning

    This 12 week, progressive stretching and toning course will aid participants in building whole body strength and flexibility by utilizing weights, chairs, mats, and various other exercise equipment. Sessions will meet three times a week for 50 minutes and will offer 'easy' and 'hard' modifications taught by an exercise leader.

    Behavioral: Stretching and Toning

  • Experimental
    Aerobic Walking

    Participants will partake in treadmill walking that encourages them to reach a pre-determined heart rate range. Sessions will be conducted three times a week for 50 minutes, and offer participants to self-select a speed and incline to meet their target heart rate zone.

    Behavioral: Aerobic Walking

Interventions

  • BehavioralYoga

    12 weeks, total of 150 minutes of exercise per week.

  • BehavioralStretching and Toning

    12 weeks, total of 150 minutes of exercise per week.

  • BehavioralAerobic Walking

    12 weeks, total of 150 minutes of exercise per week.

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What researchers measure

Primary outcomes

  1. Cognitive Function

    Participants will complete part of the NIH Toolbox measures that assess cognitive function.

    Time frame: Change from baseline to 12 weeks will be reported

Secondary outcomes

  1. Cardiovascular Function

    Participants will complete a submaximal exercise test to reach a target heart rate within 85% of the age-predicted maximum.

    Time frame: Change from baseline to 12 weeks will be reported

Other outcomes

  1. Feasibility: Recruitment and retention rates

    Proportion of participants randomized relative to total contacts, Proportion of participants who complete follow-up questionnaires,

    Time frame: Baseline to 12-weeks

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Study locations

1 site
  • University of Illinois at Urbana-Champaign
    Urbana, Illinois 61801, United States
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References and documents

Publications

  • Gothe NP, Erlenbach ED, Streeter SL, Lehovec L. Effects of yoga, aerobic, and stretching and toning exercises on cognition in adult cancer survivors: protocol of the STAY Fit pilot randomized controlled trial. Trials. 2020 Sep 15;21(1):792. doi: 10.1186/s13063-020-04723-2. PubMed 32933561 ↗

Individual participant data

Plan to share: No

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 5, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03650322
Lead sponsor
University of Illinois at Urbana-Champaign
Responsible party
Neha P. Gothe (Assistant Professor, University of Illinois at Urbana-Champaign) — Principal investigator
First posted
Aug 28, 2018
Start date
Oct 1, 2018
Primary completion
May 30, 2020
Completion
May 30, 2020
Last update
Jul 5, 2023

Study contacts

Neha Gothe, Ph.D., M.A.
principal investigator · University of Illinois at Urbana-Champaign

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.

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