An observational study in Neurological Disorder, sponsored by University Hospital, Toulouse. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-08-21.
Sponsored by University Hospital, Toulouse · Observational
Cardiovascular autonomic neuropathy (CAN) has been shown to be an important risk factor for cardiac diseases, particularly in diabetes.
CAN may be investigated by a battery of laboratory cardiovascular autonomic reflex tests(initially described by Ewing).
First screening for CAN (as proposed in diabetic patients) can be performed by assessing heart rate (HR) response to deep breathing, blood pressure (BP) and HR response to a 5 minutes stand test
Sweat glands are innervated by thin and un myelinated sympathetic C-fibers that can be impaired in neuropathies,especially length-dependent ones. Sweating dysfunction has been shown in several neurological peripheral disorders and it has been suggested that sweating function should be included among the diagnostic tests for the early detection of autonomic neuropathies. Several methods have been developed, but the lack of easy and quick tests to diagnose sweating dysfunction has restricted widespread use in clinical practice. Measurement of electrochemical skin conductance (ESC) using Sudoscan® is a new method for quick, non-invasive and quantitative assessment of sweating. This technique has demonstrated its usefulness in detecting autonomic and small fiber neuropathy, especially in diabetic patients.The aim of this study was to evaluate the performance of the laboratory battery of CV tests and of sweating dysfunction by Sudoscan®, alone or in combination, to differentiate MSA-P from PD. Among the CV tests, the present study particularly looked at those tests already recommended as screening bedside tests in diabetic patients (HR variations with deep breathing and BP variations during stand test) ; these tests are rapid and easy to perform. HR variations with deep breathing depend on parasympathetic tone and BP variations depend on vasomotor sympathetic response.
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This study's enrollment of 450 is above the median of 127 across 318 observational studies indexed under Nervous System Diseases.
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Patients referred to the autonomic laboratory of the neurology department at Toulouse University Hospital
Exclusion Criteria:
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Patients with multiple systeme atrophy (MSA) with predominant parkinsonism (MSA-P) had evaluation of cardiovascular function and sweating function
Procedure: sweating function · Procedure: Cardiovascular function
Parkinson's disease (PD) patients had evaluation of cardiovascular function and sweating function
Procedure: sweating function · Procedure: Cardiovascular function
Sweating dysfunction by Sudoscan
Also known as: sweating dysfunction by Sudoscan
Cardiovascular (CV) tests
Sweating autonomic test
Evaluate the performance of the laboratory battery of CV tests and of sweating dysfunction to differentiate MSA-P from PD
Time frame: baseline
No study locations are listed for this record.
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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University Hospital, Toulouse