An interventional study of intratympanic application of gentamicin and microsurgical removal of vestibular schwannoma in Vestibular Schwannoma and Vestibular Function Disorder, sponsored by Charles University, Czech Republic. Completed at 1 site in Czechia. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2018-08-20.
Sponsored by Charles University, Czech Republic · Not applicable, Interventional, and Treatment
The aim of this study is to assess effect of psychiatric profile on visual sensitivity and overall health status in patients who underwent surgery for vestibular schwannoma and were prehabituated by chemical vestibular ablation.
82 studies on the registry are indexed under Neurilemmoma; 21 are open to participants now.
This study's enrollment of 37 is above the median of 21 across 47 interventional studies indexed under Neurilemmoma.
Browse Neurilemmoma studies →Charles University, Czech Republic is the lead sponsor of 220 studies on the registry; 76 are open to participants now.
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Exclusion Criteria:
Patients who underwent prehabituation by gentamicin prior to surgery for vestibular schwannoma. They underwent intratympanic application of gentamicin and microsurgical removal of vest. schwannoma.
Procedure: intratympanic application of gentamicin · Procedure: microsurgical removal of vestibular schwannoma
patients without prehabituation before surgery. They underwent microsurgical removal of vest. schwannoma.
Procedure: microsurgical removal of vestibular schwannoma
under local anesthesia is gentamicin instilled through tympanic membrane to tympanic cavity
surgery under general anesthesia
change of optokinetic nystagmus measurement
During electronystagmography gain of optokinetic nystagmus is measured before and after the intervention
Time frame: change of the gain of optokinetic nystagmus among 3 time points is measured: before intervention, 1 week after intervention, 3 months after intervention
Plan to share: Undecided — It is planned to share the data concerning description of pathology (size of the tumour), outcomes of clinical examination- objective vestibular measures, outcomes of questionnaires (QoL, depression/anxiety scale)
This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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Charles University, Czech Republic