An interventional study of Virtual Reality and Exercise Therapy in Parkinson Disease, Virtual Reality Therapy and Functional Magnetic Resonance Imaging, sponsored by Farzin Hajebrahimi, PT, MSc. Terminated at 1 site in Turkey. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2021-10-19.
Sponsored by Farzin Hajebrahimi, PT, MSc · Not applicable, Interventional, and Treatment
Parkinson's Disease (PD) is one of the most common neurodegenerative disease. Bradykinesia, tremor, resting tremor and postural instability are the main motor characteristics of this disease. As the disease progresses, mobility, walking, balance are reducing, the risk of falls is increasing and patients become functionally dependent. Along with these symptoms, cognitive functions are also disturbed. The most commonly distorted cognitive functions are executive functions such as planning and reasoning, working memory, episodic memory, attention and visual-spatial skills. Pharmacological and surgical treatments are used in Parkinson's disease. Pharmacologic treatment has a proven effect on motor symptoms, but since there is no approved pharmacologic treatment which has a direct effect on cognitive functions, recent studies suggest non-pharmacological treatments to improve cognitive function. Physiotherapy is also accepted among non-pharmacological treatments. Conventional physiotherapy focuses on optimizing patient independence and safety, focusing on hinting strategies, cognitive movement strategies and exercises utilizing transfers, posture, upper extremity function, balance (and falls), gait, physical capacity and (in)activity. Virtual Reality (VR) technology, a promising commonly used new rehabilitation tool, is a treatment method that can be used as one of the non-pharmacological treatment methods in Parkinson's Disease. In order to understand how neuronal network dysfunction in the Parkinson's Disease leads to clinical symptoms, both the component elements and the interconnections within these networks need to be examined in greater detail. Studies of resting state-fMRI (rs-fMRI) use correlation of activation of brain regions and time series fluctuations between brain regions to give information about connectivity in brain.
The purpose of this study is to investigate the therapeutic effects of virtual reality on motor and cognitive symptoms of PD. Furthermore, the investigation of possible effects of this effect on neuroplasticity through functional brain networks is our other objective. This study will be the first study to evaluate the plasticity effect of virtual reality application with rs-fMRI in Parkinson's disease.
4,487 studies on the registry are indexed under Parkinson Disease; 1,082 are open to participants now.
This study's enrollment of 30 is below the median of 40 across 3,294 interventional studies indexed under Parkinson Disease.
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Exclusion Criteria:
Virtual Reality will be applied in addition to the Anti-parkinsonian medication given by the Neurologist.
Behavioral: Virtual Reality
Exercise Therapy will be applied in addition to the Anti-parkinsonian medication given by the Neurologist.
Behavioral: Exercise Therapy
Virtual Reality Based Rehabilitation including static balance, dynamic balance and walking
Also known as: Nintendo Wii
The conventional physical Therapy program includes parameters for improving strength, flexibility, transfers, posture, balance and coordination, and sensory stimulation. These activities consist of various types of exercises that focus on lower extremity movements.
Also known as: Conventional Physical Therapy
Motor Level
Unified Parkinson's Disease Rating Scale-Motor (UPDRS-III)
Time frame: Change from Baseline at 4 weeks.
Cognitive Level
Montreal Cognitive Asssessment (MoCA)
Time frame: Change from Baseline at 4 weeks.
Neuroplasticity
Resting State Networks functional connectivity
Time frame: Change from Baseline at 4 weeks.
Balance
Berg Balance Scale (BBS)
Time frame: Change from Baseline at 4 weeks.
Quality of Life in patients with Parkinson's Disease
The Parkinson's Disease Questionnaire (PDQ-39)
Time frame: Change from Baseline at 4 weeks.
Mobility
Timed Up and Go Test (TUG),
Time frame: Change from Baseline at 4 weeks.
Functional Capacity
Six Minute Walk Test (6MWT)
Time frame: Change from Baseline at 4 weeks.
Depression
The Geriatric Depression Scale (GDS)
Time frame: Change from Baseline at 4 weeks.
Balance Confidence
The Activities-specific Balance Confidence (ABC) Scale
Time frame: Change from Baseline at 4 weeks.
Cognitive Assessment
Neuropsychological assessment test (NPT) battery
Time frame: Change from Baseline at 4 weeks.
Plan to share: No — Individual participant data will not be available to the public.
This study is terminated, as verified in Oct 2021. You cannot join it, but the record below documents what was studied.
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