An observational study in Dental Trauma, Avulsion and Periodontal Regeneration, sponsored by University of Bern. Completed at 1 site in Switzerland. Open to participants aged 6 Years and older. Per ClinicalTrials.gov, last updated 2018-08-21.
Sponsored by University of Bern · Observational
To evaluate the effect of topical tetracycline and dexamethasone on periodontal and pulpal regeneration of avulsed permanent teeth after an observation period between 9-16 years.
Two different medications were applied prior to replantation. A) Topical tetracycline, B) topical dexamethasone. Teeth were splinted using a non-rigid titanium trauma splint for 7-14 days. Endodontic treatment was performed within 1-7 days, except for teeth with an open apex and a short extraoral dry time. All patients received systemic tetracycline for 10 days after accident and were subsequently re-examined.
Follow-up examinations included periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow, periapical radiograph and intraoral photographs. Additionally a OHIP-14 questionnaire was carried out to determine the oral health-related quality of life.
16 studies on the registry are indexed under Fractures, Avulsion; 4 are open to participants now.
Browse Fractures, Avulsion studies →University of Bern is the lead sponsor of 209 studies on the registry; 47 are open to participants now.
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Patients with avulsed permanent teeth who were treated between 2000-2008 at the Department of Oral Surgery, zmk Bern
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation
Procedure: Tetracycline
Teeth were soaked in dexamethasone (60μ ml-1) for 20 minutes before replantation
Procedure: Dexamethasone
Teeth were soaked in topical tetracycline 5% for 5 minutes before replantation
Teeth were soaked in topical dexamethasone (60μ ml-1) for 20 minutes before replantation
Number of teeth with periodontal regeneration
Periodontal regeneration was assessed with periodontal examination, percussion, Periotest measurements and periapical radiograph.
Time frame: After a mean observation period of 12.9±2.4 years (one visit only)
Number of teeth with pulpal regeneration
Pulpal regeneration was assessed with periodontal examination, percussion, Periotest measurements, pulp sensitivity using CO2 snow and periapical radiograph.
Time frame: After a mean observation period of 12.9±2.4 years (one visit only)
Number of teeth that survived
Assessed by visual inspection
Time frame: After a mean observation period of 12.9±2.4 years (one visit only)
Number of teeth with open versus closed apex at accident
Assessed by x-ray
Time frame: At baseline
Patients satisfaction
Measured by OHIP-14 score
Time frame: After a mean observation period of 12.9±2.4 years (one visit only)
Plan to share: No
No publications or documents are linked to this record.
Ran from Aug 2000 to primary completion in Oct 2017, 205 months.
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This study is completed, as verified in Aug 2018. You cannot join it, but the record below documents what was studied.
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