CompletedNCT03607409Updated Aug 8, 2019

Role of Inhibin A as Biomarker for Ovarian Response for IVF Treatment

An observational study in Infertility, sponsored by ART Fertility Clinics LLC. Completed at 1 site in United Arab Emirates. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2019-08-08.

Sponsored by ART Fertility Clinics LLC · Observational

Study type: Observational
Model: Case-only
Time perspective: Prospective
Enrollment: 150
Ages: 18 Years to 40 Years
Sex: Female

Study summary

To evaluate the role of Inhibin A as bio marker for the number of mature oocytes, compared to Estradiol

Read the detailed description

Inhibin A could be an improved biomarker regarding the number of expected mature oocytes compared to estradiol.

Conditions studied

Infertility

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In context

Infertility

2,506 studies on the registry are indexed under Infertility; 407 are open to participants now.

This study's enrollment of 150 is below the median of 200 across 714 observational studies indexed under Infertility.

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Lead sponsor

ART Fertility Clinics LLC is the lead sponsor of 51 studies on the registry; 20 are open to participants now.

Counted across the registry records on this site, refreshed daily.

Who can participate

Ages eligible: 18 Years to 40 Years
Sexes eligible: Female
Accepts healthy volunteers: Yes
Sampling method: Non-probability sample

Study population

Patients undergoing ovarian stimulation for IVF treatment

Inclusion criteria

Patients undergoing ovarian stimulation with gonadotropins in either a GnRH-agonist or GnRH-antagonist for IVF treatment due to primary / secondary infertility.

Exclusion criteria

Exclusion Criteria:

Patients undergoing a modified natural cycle stimulation protocol (Taymour cycle) Patients at risk for development of ovarian hyperstimulation syndrome (OHSS)

Study design

Observational model: Case-only
Time perspective: Prospective
Enrollment: 150 participants (actual)
Patient registry: No
Biospecimen retention: Samples with dna

What researchers measure

Primary outcomes

Number of mature oocytes
Patients undergoing ovarian stimulation with gonadotropins
Time frame: 1 year

Study locations

1 site

IVI Middle East Fertilty Clinic
Abu Dhabi, 60202, United Arab Emirates

References and documents

Publications

Schneyer AL, Fujiwara T, Fox J, Welt CK, Adams J, Messerlian GM, Taylor AE. Dynamic changes in the intrafollicular inhibin/activin/follistatin axis during human follicular development: relationship to circulating hormone concentrations. J Clin Endocrinol Metab. 2000 Sep;85(9):3319-30. doi: 10.1210/jcem.85.9.6767. PubMed 10999828 ↗
Hohmann FP, Laven JS, de Jong FH, Fauser BC. Relationship between inhibin A and B, estradiol and follicle growth dynamics during ovarian stimulation in normo-ovulatory women. Eur J Endocrinol. 2005 Mar;152(3):395-401. doi: 10.1530/eje.1.01871. PubMed 15757856 ↗
Abbara A, Vuong LN, Ho VNA, Clarke SA, Jeffers L, Comninos AN, Salim R, Ho TM, Kelsey TW, Trew GH, Humaidan P, Dhillo WS. Follicle Size on Day of Trigger Most Likely to Yield a Mature Oocyte. Front Endocrinol (Lausanne). 2018 Apr 25;9:193. doi: 10.3389/fendo.2018.00193. eCollection 2018. PubMed 29743877 ↗

Individual participant data

Plan to share: No

Updates

Tracking since Sep 25, 2026

No changes since tracking began. The registry record was last updated on Aug 8, 2019, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗

Registry details

Key details

Study ID: NCT03607409
Lead sponsor: ART Fertility Clinics LLC
Collaborators: Ansh Labs
Responsible party: Barbara Lawrenz (Scientific Director, ART Fertility Clinics LLC) — Principal investigator
First posted: Jul 31, 2018
Start date: Sep 9, 2018
Primary completion: Jan 29, 2019
Completion: Jul 4, 2019
Last update: Aug 8, 2019

Study contacts

Barbara Lawrenz, PhD

principal investigator · ART Fertility Clinics LLC

Oversight

Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2019. You cannot join it, but the record below documents what was studied.

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Discussion

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