An observational study in Lymphoblastic Leukemia in Children, sponsored by Air Force Military Medical University, China. Completed at 1 site in China. Open to participants aged Up to 16 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-07-10.
Sponsored by Air Force Military Medical University, China · Observational
Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of acute lymphoblastic leukemia (ALL).The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for ALL.
5,442 studies on the registry are indexed under Leukemia; 637 are open to participants now.
This study's enrollment of 300 is above the median of 120 across 744 observational studies indexed under Leukemia.
Browse Leukemia studies →Air Force Military Medical University, China is the lead sponsor of 172 studies on the registry; 36 are open to participants now.
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A total of 150 eligible chronic lymphocytic leukemia patients were anticipated to include in this study. Moreover, 50 healthy controls without previous cancer history were also recruited from individuals who visited investigator's hospital for physical examination during the same time period.
Exclusion Criteria:
150 patients were recruited, who have diagnosed with acute leukemia by bone marrow biopsy
Diagnostic Test: Relative copy number of mitochondrial DNA
The 50 healthy controls without previous cancer history were recruited from individuals who visited investigator's hospital for physical examination during the same time period as the case enrollment.
Diagnostic Test: Relative copy number of mitochondrial DNA
Mitochondria are responsible for multiple cellular functions including regulation of energy production, modulation of oxidation-reduction status, generation of reactive oxygen species and apoptosis. Each mitochondrion possesses multiple copies of a mitochondrial genome comprised of independently replicating double stranded DNA (mtDNA).
Relative copy number of mitochondrial DNA
The ratio of mitochondrial DNA contents to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from chronic lymphocytic leukemiawhen compared with control group.
Time frame: From date of admission until the date of discharging from hospital, assessed up to 5 days
Plan to share: No
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This study is completed, as verified in Jul 2020. You cannot join it, but the record below documents what was studied.
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Air Force Military Medical University, China