An interventional study of enteral nutrition in Nutrition Disorders, sponsored by Masaryk University. Completed at 1 site in Czechia. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2026-10-16.
Sponsored by Masaryk University · Not applicable, Interventional, and Treatment
The purpose of the study is to compare continuous versus intermittent strategy for enteral nutrition. The study will examine if there is a difference in achieving nutritional delivery goals, tolerance and number of complications of enteral nutrition.
The study will commence following the Approval by The Ethics Research Committee. All patients admitted to our ICU from the 1st of June 2018 to the 31st of May 2019 will be enrolled after fulfilling the inclusion criteria and in the absence of any exclusion criteria. Informed consent will be requested. Enteral nutrition will be administered via nasogastric of orogastric tube. Patients will be randomised in 2 groups. In the group of patients receiving continuous feeding will be enteral nutrition administered via enteral feeding pump for at least 16 hours par day. In the group of patients receiving intermittent feeding will be enteral nutrition administered as 30-60minutes lasting bolus via enteral feeding pump 6 times per day. Following the administration of the bolus the patient will be placed for 30 minutes in semi-upright sitting position. Enteral nutrition requirement and composition will be standardised with the adoption of international guidelines. In 5 subsequent days from the enteral nutrition commencement will be examined if there is a difference in achieving energy and protein targets, tolerance and number of complications of enteral nutrition in between both groups. As achievement of energy and protein targets will be considered at least 80% of calculated values. The tolerance of enteral nutrition will be evaluated by the clinical examination of the abdomen, presence of diarrhoea, vomiting and the gastric residual volume of at least 0,5 liter. As the complications of enteral nutrition will be regarded the aspiration of gastric contents and ventilator associated pneumonia. Nutritional status parameters will be analysed. the length of hospital stay, ICU length of stay and 28-day mortality will be also monitored.
279 studies on the registry are indexed under Nutrition Disorders; 31 are open to participants now.
This study's enrollment of 300 is above the median of 115 across 198 interventional studies indexed under Nutrition Disorders.
Browse Nutrition Disorders studies →Masaryk University is the lead sponsor of 45 studies on the registry; 20 are open to participants now.
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Exclusion Criteria:
enteral nutrition will be administered via enteral feeding pump as 30-60minutes lasting bolus 6 times per day volume of initial bolus will be 80ml. The volume of bolus will be increased gradually according to tolerance, till the estimated target rate will be reached
Other: enteral nutrition
enteral nutrition will be administered via enteral feeding pump for at least 16 hours par day initial rate will be 25ml/hour. The rate will be increased gradually according to tolerance, till the estimated target rate will be reached
Other: enteral nutrition
administration of enteral nutrition
Energy target
Daily assessment of energy intake in critically ill patients with enteral nutrition.Energy target will be achieved if at least 80% of calculated energy intake will be delivered.
Time frame: 5 days from initiation of enteral nutrition
Protein target
Daily assessment of protein intake in critically ill patients with enteral nutrition.Protein target will be achieved if at least 80% of calculated protein intake will be delivered.
Time frame: 5 days from initiation of enteral nutrition
Tolerance of enteral nutrition
Measurement of the gastric residual volume
Time frame: 5 days from initiation of enteral nutrition
Tolerance of enteral nutrition
Incidence of diarrhoea
Time frame: 5 days from initiation of enteral nutrition
Tolerance of enteral nutrition
Incidence of vomiting
Time frame: 5 days from initiation of enteral nutrition
Complications of enteral nutrition
Incidence of aspiration and ventilator associated pneumonia
Time frame: 5 days from initiation of enteral nutrition
Nutritional status
Blood test : total serum protein test
Time frame: On admission and day 5 from initiation of enteral nutrition
Nutritional status
Blood test : albumin test
Time frame: On admission and day 5 from initiation of enteral nutrition
Nutritional status
Blood test : prealbumin test
Time frame: On admission and day 5 from initiation of enteral nutrition
ICU and hospital length of stay
Time frame: through study completion, an average of 3 weeks
28-day mortality
Time frame: 28 days from randomisation
Plan to share: No
Ran from Nov 2018 to primary completion in Dec 2022, 48 months.
Of 73 non-industry interventional studies with no phase under Nutrition Disorders, half reached primary completion within 18 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 41. This study's 48 months is above that.
Counting every sponsor, half of 77 studies reached it within 15 months; a quarter within 8 and three quarters within 36.
Primary completion moved once since we started tracking on Sep 25, 2026: Jun 2023 → Dec 2022, on Oct 16, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
This study is completed, as verified in Jun 2025. You cannot join it, but the record below documents what was studied.
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Masaryk University