An observational study in Arthritis, Rheumatoid and Stress Disorder, sponsored by University Hospital, Bordeaux. Completed at 5 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-09-12.
Sponsored by University Hospital, Bordeaux · Observational
Rheumatoid Arthritis (RA) is an inflammatory rheumatic disease that can lead to structural damage and handicap. The RA physiopathology is multifactorial, including genetic and environmental risk factors. The identification of environmental factors implication is crucial to understand the RA mechanism, and improves the diagnosis and the treatment of the disease.
The physiopathology of RA is multifactorial, implicating genetic and environmental factors. Within the environmental factors, the exact role of psychological stress and life events on the onset of the disease is still under question. In clinical practice, patients usually report the occurrence of a stressing life event before the diagnosis of the disease (mourning, dismissal, divorce…). Nevertheless, literature reviews present some discrepancies and did not lead to a clear identification of the role of psychological stress in RA onset. This is mainly due to the evaluation methods of stress within those previous studies, considering stress as a unique response of the organism without taking into account personal, sociological, biological or environmental history. The aim of the study is to analyze the impact of stress on the RA onset within an integrative model, to evaluate patient assessment of the stress, and to present strategies to fix it.
2,962 studies on the registry are indexed under Arthritis, Rheumatoid; 396 are open to participants now.
This study's enrollment of 152 is below the median of 176 across 854 observational studies indexed under Arthritis, Rheumatoid.
Browse Arthritis, Rheumatoid studies →University Hospital, Bordeaux is the lead sponsor of 803 studies on the registry; 194 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients affected by RA according to ACR/EULAR 2010 criteria, with a disease duration less than 2 years
Patients RA :
Inclusion Criteria:
Exclusion Criteria:
Control :
Inclusion Criteria:
Exclusion Criteria:
patients affected by RA according to ACR/EULAR 2010 criteria, with a disease duration less than 2 years
Behavioral: Questionnaire · Biological: blood sample
patients with a visceral surgery for less than 2 years (appendectomy, cholecystectomy, bowel obstruction, hernia, eventration…)
Behavioral: Questionnaire
Questionnaire
7 ml whole blood for Peripheral blood
Life events calculated over the year preceding the onset of PR symptoms
Social Readjustment Rating Scale (SRRS)
Time frame: At inclusion (day 0)
Perceived stress
Perceived Stress Scale (PSS)
Time frame: At inclusion (day 0)
Perceived control
Multidimensional Health Locus of Control Scale (MHLCS)
Time frame: At inclusion (day 0)
Perceived social support
Social Support Questionnaire (SSQ)
Time frame: At inclusion (day 0)
State Anxiety
State-Trait Anxiety Inventory (STAI-Y-A)
Time frame: At inclusion (day 0)
Coping
Ways of Coping Checklist Scale (WCC)
Time frame: At inclusion (day 0)
Cytokine levels in RA patients sera
Time frame: 12 months from baseline
Correlation between cytokine levels and RA activity
Time frame: 12 months from baseline
Correlation between cytokine levels and stress for RA patients
Time frame: 12 months from baseline
Identification of neuropathic pain for RA patients evalued by douleur-neuropathique 10 items questionnaire
douleur-neuropathique 10 items questionnaire providing a score between 0 and 10, with a positive threshold value beyond 4/10.
Time frame: 12 months from baseline
Characterization of neuropathic pain for RA patients evalued by Neuropathic Pain Symptom Inventory questionnaire
Neuropathic Pain Symptom Inventory questionnaire with 12 items to complete, providing for each item the presence (or the absence) of several pain symptoms
Time frame: 12 months from baseline
This study is completed, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University Hospital, Bordeaux →