An observational study in Heart Arrest and Targeted Temperature Management, sponsored by Sang Hoon Oh. Status unknown at 1 site in Korea, Republic of. Open to participants aged 19 Years and older. Per ClinicalTrials.gov, last updated 2019-09-26.
Sponsored by Sang Hoon Oh · Observational
This study aims to examine the prognostic value of 18 channel amplitude-integrated EEG (aEEG) in comatose cardiac arrest patients The study design is a prospective observational study. Cardiac arrest patients undergoing targeted temperature management (TTM) will participate in the study. Relation of aEEG in each channel with the neurologic outcome at 6 month after return of spontaneous circulation (ROSC) will be evaluated.
Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was >10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was >5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels.
966 studies on the registry are indexed under Heart Arrest; 227 are open to participants now.
This study's enrollment of 78 is below the median of 200 across 383 observational studies indexed under Heart Arrest.
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TTM treated cardiac arrest patients
Comatose cardiac arrest TTM treatment Multi channel aEEG monitoring
Exclusion Criteria:
Cerebral origin cardiac arrest Known epilepsy
CPC 1 and 2 at 6 month after ROSC
Diagnostic Test: Multi-channel aEEG monitoring
CPC 3 to 5 at 6 month after ROSC
Diagnostic Test: Multi-channel aEEG monitoring
18 channel aEEG monitoring in comatose TTM-treated patients
Time to normal trace in each aEEG channel
Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels.
Time frame: at day 180
TTNT threshold for neurologic prognostication in each aEEG channel
Using area under the curve (AUC) of each channel aEEG for neurological outcome, we will determine the best TTNT thresholds for good neurological outcome (CPC 1 to 2) in all aEEG channels.
Time frame: at day 180
Alpha delta ratio of each channel aEEG for good neurological outcome (CPC 1 to 2)
The percentage powers in the alpha, theta and delta bands and the ratio of the powers in different frequency bands (i.e., alpha/delta) will be calculated. Finally we will evaluate the prognostic values of these ratios of the different bands.
Time frame: at day 180
Comparison of prognostic value between aEEG and various predictors
We will compare the prognostic performances (i.e., sensitivity, specificity, AUC) for poor neurological outcome (CPC 3 to 5) between EEG and these predictors.
Time frame: at day 180
This study is status unknown, as verified in Sep 2019. You cannot join it, but the record below documents what was studied.
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