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Status unknownNCT03513653STRATS-AHFUpdated Apr 12, 2023

Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry

An observational study in Heart Failure Acute, Heart Failure and Echocardiography, sponsored by Seoul National University Hospital. Status unknown at 3 sites in Korea, Republic of. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2023-04-12.

Sponsored by Seoul National University Hospital · Observational

The sponsor has not verified this record recently (last verified Apr 2023), so the status shown — last known as Active, not recruiting — may be out of date.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
4,312
Ages
18 Years and older
Sex
All
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Study summary

STRATS-AHF (STrain for Risk Assessment and Therapeutic Strategies in patients with Acute Heart Failure) registry enrolled 4,312 patients hospitalized for acute HF from 3 tertiary university hospitals (Seoul National University Bundang Hospital, Seoul National University Hospital, and Chungnam National University Hospital) from January 2009 through December 2016.

Read the detailed description

Patients with signs or symptoms of heart failure and either lung congestion, or objective findings of left ventricular (LV) systolic dysfunction or structural heart disease, were eligible for the study. Echocardiography was performed and both LV ejection fraction (LVEF) and LV global longitudinal strain (LV-GLS), right ventricular GLS (RV-GLS) were measured.

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Conditions studied

  • Heart Failure Acute
  • Heart Failure
  • Echocardiography

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Keywords

  • acute heart failure
  • global longitudinal strain
  • ejection fraction
  • echocardiography
  • mortality
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In context

Heart Failure

5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.

This study's enrollment of 4,312 is above the median of 200 across 1,679 observational studies indexed under Heart Failure.

Browse Heart Failure studies →

Lead sponsor

Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients hospitalized for acute heart failure

Inclusion criteria

  • Patients with signs or symptoms of HF and either lung congestion, or objective findings of LV systolic dysfunction or structural heart disease

Exclusion criteria

Exclusion Criteria:

  • Patients who presented with acute coronary syndrome
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
4,312 participants (actual)
Patient registry
No

Groups and cohorts

  • Acute heart failure

    Patients hospitalized for acute heart failure and underwent echocardiography with speckle-tracking imaging

    Diagnostic Test: Echocardiography with speckle-tracking imaging

Interventions

  • Diagnostic testEchocardiography with speckle-tracking imaging

    1. Measurement of left ventricular ejection fraction and global longitudinal strain 2. Measurement of left atrial reservoir strain (peak atrial longitudinal strain) 3. Measurement of right ventricular global longitudinal strain

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What researchers measure

Primary outcomes

  1. All-cause mortality

    Death from any cause

    Time frame: up to 5 years

Secondary outcomes

  1. Hospitalization for heart failure

    Any hospitalization for acute heart failure after the index hospitalization

    Time frame: up to 5 years

  2. Composite of all-cause mortality and hospitalization for heart failure

    Death from any cause or any hospitalization for acute heart failure after the index hospitalization

    Time frame: up to 5 years

  3. Ischemic stroke

    Ischemic stroke (an episode of neurological dysfunction caused by embolism) after the index hospitalization

    Time frame: up to 5 years

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Study locations

3 sites
  • Seoul National University Bundang Hospital
    Seongnam-si, Gyeonggi-do 13620, Korea, Republic of
  • Chungnam National University Hospital
    Daejeon, 35015, Korea, Republic of
  • Seoul National University Hospital
    Seoul, 03080, Korea, Republic of
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References and documents

Publications

  • Park JJ, Park JB, Park JH, Cho GY. Global Longitudinal Strain to Predict Mortality in Patients With Acute Heart Failure. J Am Coll Cardiol. 2018 May 8;71(18):1947-1957. doi: 10.1016/j.jacc.2018.02.064. PubMed 29724346 ↗
  • Park JH, Park JJ, Park JB, Cho GY. Prognostic Value of Biventricular Strain in Risk Stratifying in Patients With Acute Heart Failure. J Am Heart Assoc. 2018 Oct 2;7(19):e009331. doi: 10.1161/JAHA.118.009331. PubMed 30371332 ↗
  • Hwang IC, Cho GY, Choi HM, Yoon YE, Park JJ, Park JB, Park JH, Lee SP, Kim HK, Kim YJ, Sohn DW. Derivation and validation of a mortality risk prediction model using global longitudinal strain in patients with acute heart failure. Eur Heart J Cardiovasc Imaging. 2020 Dec 1;21(12):1412-1420. doi: 10.1093/ehjci/jez300. PubMed 31819981 ↗
  • Park JJ, Choi HM, Hwang IC, Park JB, Park JH, Cho GY. Myocardial Strain for Identification of beta-Blocker Responders in Heart Failure with Preserved Ejection Fraction. J Am Soc Echocardiogr. 2019 Nov;32(11):1462-1469.e8. doi: 10.1016/j.echo.2019.06.017. Epub 2019 Sep 17. PubMed 31540679 ↗
  • Park JH, Hwang IC, Park JJ, Park JB, Cho GY. Prognostic power of left atrial strain in patients with acute heart failure. Eur Heart J Cardiovasc Imaging. 2021 Jan 22;22(2):210-219. doi: 10.1093/ehjci/jeaa013. PubMed 32031588 ↗
  • Park CS, Park JB, Park JJ, Park JH, Cho GY. Impact of sex and myocardial function on association of obesity with mortality in Asian patients with acute heart failure: a retrospective analysis from the STRATS-AHF registry. BMJ Open. 2020 Feb 10;10(2):e031608. doi: 10.1136/bmjopen-2019-031608. PubMed 32047009 ↗
  • Park JJ, Mebazaa A, Hwang IC, Park JB, Park JH, Cho GY. Phenotyping Heart Failure According to the Longitudinal Ejection Fraction Change: Myocardial Strain, Predictors, and Outcomes. J Am Heart Assoc. 2020 Jun 16;9(12):e015009. doi: 10.1161/JAHA.119.015009. Epub 2020 Jun 10. PubMed 32519555 ↗
  • Park JJ, Park JH, Hwang IC, Park JB, Cho GY, Marwick TH. Left Atrial Strain as a Predictor of New-Onset Atrial Fibrillation in Patients With Heart Failure. JACC Cardiovasc Imaging. 2020 Oct;13(10):2071-2081. doi: 10.1016/j.jcmg.2020.04.031. Epub 2020 Jul 15. PubMed 32682715 ↗
  • Park CS, Park JJ, Hwang IC, Park JB, Park JH, Cho GY. Myocardial strain to identify benefit from beta-blockers in patients with heart failure with reduced ejection fraction. ESC Heart Fail. 2022 Apr;9(2):1248-1257. doi: 10.1002/ehf2.13800. Epub 2022 Jan 9. PubMed 35001562 ↗
  • Park CS, Hwang IC, Park JJ, Park JH, Park JB, Cho GY. Determinants of the survival benefit associated with statins in patients with acute heart failure. ESC Heart Fail. 2021 Dec;8(6):5424-5435. doi: 10.1002/ehf2.13637. Epub 2021 Oct 5. PubMed 34612019 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 12, 2023, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT03513653
Lead sponsor
Seoul National University Hospital
Collaborators
Seoul National University Bundang Hospital, Chungnam National University Hospital
Responsible party
Goo-Yeong Cho (Professor, Seoul National University Bundang Hospital) — Principal investigator
First posted
May 1, 2018
Start date
Jan 1, 2009
Primary completion
Sep 5, 2017
Completion
Dec 31, 2023 (estimated)
Last update
Apr 12, 2023

Study contacts

Goo-Yeong Cho, MD, PhD
principal investigator · Seoul National University Bundang Hospital

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2023. You cannot join it, but the record below documents what was studied.

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