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CompletedNCT03488511Updated Feb 19, 2020

The Impact of Preoperative FoodforCare at Home

An interventional study of FoodforCare at home in Surgery, sponsored by Radboud University Medical Center. Completed at 2 sites in Netherlands. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-02-19.

Sponsored by Radboud University Medical Center · Not applicable, Interventional, and Supportive care

Phase
Not applicable
Study type
Interventional
Enrollment
126
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Preoperative nutritional state is closely related to perioperative morbidity and complications. This study aims to determine the effect of a protein-rich meal service in the preoperative setting compared to usual care.

Read the detailed description

Each year, approximately 1.4 million patients in the Netherlands are operated. Adequate nutritional intake, mainly protein intake, before surgery is important to improve preoperative muscle strength and functional capacity. However, up to 40% of patients admitted to the hospital suffer from malnutrition and this further deepened during hospitalization, which is an independent risk factor for peri-operative morbidity and severe complications, ranging from increased muscle loss, to higher infection rates, delayed wound healing and subsequently a prolonged hospital stay. An adequate food service is one strategy to improve protein intake and thereby the nutritional status. Extension of the study period to the out-of-hospital setting is recommended to explore the effects of long-term exposure to this concept on nutritional, functional and clinical outcomes. Therefore, the investigators aim to evaluate whether home delivered protein-rich meals, as part of FoodforCare meal service, in the preoperative setting improves protein intake in patients undergoing surgery, compared to usual care. The second aim is to investigate the effects on functional and clinical outcomes.

02

Conditions studied

  • Surgery
03

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Inclusion criteria:

  • 18 years or older
  • surgical patients
  • living within a 40 km radius around Nijmegen/Veghel
  • inclusion at least 4 weeks before surgery
  • surgery: Urology, Orthopedics, Gynaecology, General Surgery
  • oral intake

Exclusion criteria:

  • renal insufficiency (MDRD-GFR (glomerular filtration rate) \< 60ml/min and/or proteinuria)*
  • food allergy
  • planned vacation during intervention period

    • proteinuria is defined in case of a protein creatinine ratio > 0.5g/10mmol or an albuminuria > 300mg/day.
04

Study design

Phase
Not applicable
Primary purpose
Supportive care
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
126 participants (actual)

Study arms

  • Experimental
    Intervention group

    The intervention group will receive meals from FoodforCare at Home. The FoodforCare at Home concept consists of six small protein and energy enriched meals and snacks that will be delivered twice a week. After an individual intake, the composition of the dishes will be tailored to the needs of the patient in terms of composition, diet, taste, flavor and portion size. Besides the meals, patients in the intervention group will also receive an information leaflet about the importance of protein during treatment and how to reach their protein requirements.

    Other: FoodforCare at home

  • No intervention
    Control group

    The control group will continue their usual diet for 3 weeks and have no restrictions to their diet.

Interventions

  • OtherFoodforCare at home

    Six small protein rich meals that will be delivered twice a week for 3 weeks.

05

What researchers measure

Primary outcomes

  1. Protein intake relative to requirements

    3-day food diary filled in at baseline and after 3 weeks.

    Time frame: 3 weeks

Secondary outcomes

  1. Nutritional status

    Patient Generated Subjective Global Assessment (PG-SGA) performed at baseline and after 3 weeks.

    Time frame: 3 weeks

  2. Quality of life and overall health status

    ShortForm-36 questionnaire filled in at baseline and after 3 weeks. This questionnaire consists of 36 questions about physical and psychological aspects. Each item is scored on a 0 to 100 range. The higher the score, the higher the quality of life of the patient.

    Time frame: 3 weeks

  3. Patient satisfaction

    Questionnaire filled in after 3 weeks of receiving meals. This is a self-developed questionnaire which does not have a total score. Each question will be analyzed separately. Questions consist of grading from 0-10 (the higher, the better the outcome) or with a 5-point Likert scale (completely disagree-completely agree).

    Time frame: 3 weeks

  4. Length of stay

    These are determined retrospectively in the electronic patient file EPIC 2 months after baseline

    Time frame: 2 months

  5. Readmissions

    These are determined retrospectively in the electronic patient file EPIC 2 months after baseline

    Time frame: 2 months

  6. Postoperative complications

    This is reported using a standardized classification system 2 months after baseline

    Time frame: 2 months

  7. Energy intake relative to requirements

    3-day food diary filled in at baseline and after 3 weeks.

    Time frame: 3 weeks

  8. Functional status

    Short Physical Performance Battery (SPPB) performed at baseline and after 3 weeks.

    Time frame: 3 weeks

  9. Muscle strength

    Hand grip strength (kg) performed at baseline and at 3 weeks.

    Time frame: 3 weeks

06

Study locations

2 sites
  • Radboudumc
    Nijmegen, Gelderland 6525 GA, Netherlands
  • Maasziekenhuis Pantein
    Beugen, Noord-Brabant 5835DV, Netherlands
07

References and documents

Study documents

  • Protocol and statistical analysis plan · Jan 2, 2018

Documents are hosted by the registry — open the source record to download them.

Individual participant data

Plan to share: No

08

Registry details

Key details

Study ID
NCT03488511
Lead sponsor
Radboud University Medical Center
Responsible party
Sponsor
First posted
Apr 5, 2018
Start date
Mar 5, 2018
Primary completion
Jun 1, 2019
Completion
Sep 1, 2019
Last update
Feb 19, 2020

Study contacts

Manon van den Berg, PhD
study chair · Radboud University Medical Center

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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