An observational study in Aging, Premature, Congenital Heart Disease and White Matter Hyperintensities, sponsored by IRCCS Policlinico S. Donato. Completed at 1 site in Italy. Open to participants aged 20 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-09-13.
Sponsored by IRCCS Policlinico S. Donato · Observational
The study aims at investigating the role of cyanotic congenital heart disease (cCHD) on brain aging. The investigators assume that due to congenital and acquired cardiovascular abnormalities, cCHD patients could show radiologic (and clinical) signs of precocious brain aging and eventual cognitive decline.
White matter hyperintensities burden will be quantified through a semi-autamated software (ITK-SNAP)
1,031 studies on the registry are indexed under Heart Defects, Congenital; 262 are open to participants now.
This study's enrollment of 146 is above the median of 120 across 459 observational studies indexed under Heart Defects, Congenital.
Browse Heart Defects, Congenital studies →IRCCS Policlinico S. Donato is the lead sponsor of 103 studies on the registry; 51 are open to participants now.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
any pathological condition and/or symptomp that could alter the white matter hyperintensities burden, among which:
Other: Brain MRI · Other: Neuropsychological test battery
Other: Brain MRI
Acquisition of 3D T1-weighted, 3D FLAIR and GRE brain MRI scans
1. Mini Mental State Examination (MMSE), Measso et al. (1993); 2. Frontal Assessment Battery (FAB), Appollonio et al. (2005); 3. Symbol Digit Test, Amodio et al. (2002); 4. Digit Cancellation Test, Della Sala et al. (1992); 5. Trial Making Test (TMT A-B), Giovagnoli et al. (1996); 6. Weigl's Sorting Test, Laicona et al. (2000) and Inzaghi (2010); 7. Digit Span, Orsini et al (1987); 8. Corsi block-tapping test, Orsini et al. (1987); 9. Babcock story recall test, Carlesimo et al. (2002); 10. Phonemic verbal fluency in MDB, Caltagirone and Carlesimo (2010); 11. Semantic verbal fluency, Novelli (1986); 12. Imitating gestures, De Renzi et al. (1980); 13. Coloured Progressive Matrices (CPM47), Measso et al. (1993).
White matter hyperintensities volume expressed in mm^3
Semi-automated quantification performed through ITK-SNAP
Time frame: 3 years
Plan to share: No
This study is completed, as verified in Sep 2022. You cannot join it, but the record below documents what was studied.
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