CClinicalTrials.gg
TerminatedNCT03480919Updated Nov 12, 2019Results posted

Acupuncture for Pre-Procedure Anxiety

An interventional study of Shen Men acupuncture and Epidural injection in Anxiety, sponsored by Hospital for Special Surgery, New York. Terminated at 1 site in United States. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2019-11-12.

Sponsored by Hospital for Special Surgery, New York · Not applicable, Interventional, and Treatment

Why this study was terminated
Limited resources
Phase
Not applicable
Study type
Interventional
Enrollment
4
Allocation
Randomized
Ages
18 Years to 100 Years
Sex
All
01

Study summary

It is common for patients undergoing spinal injections to report anxiety prior to the injection. Although sedation, general anesthesia, and medications can be used to reduce anxiety, the use of sedative agents during the procedure can increase the risk of spinal cord injury. The purpose of this study is to see if receiving acupuncture before a spinal injection can effectively reduce patients' anxiety. Only patients who are scheduled to receive a spinal injection at this institution will be eligible for the study.

02

Conditions studied

  • Anxiety

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03

Who can participate

Ages eligible
18 Years to 100 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Age 18+
  • Spine pathology that meets criteria for lumbar epidural injection

Exclusion criteria

Exclusion Criteria:

  • Unable to provide consent
  • Contraindications to acupuncture (e.g., rash, skin infection, sensory loss in ear)
  • Previous experience of acupuncture
  • Age \<18
  • Pregnant women
  • Non-English or Non-Spanish speaking
04

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
4 participants (actual)

Study arms

  • Experimental
    Shen Men acupuncture

    Single acupuncture needles will be placed bilaterally onto the patient's Shen Men acupuncture point in the ear for a duration of 20 minutes.

    Device: Shen Men acupuncture · Procedure: Epidural injection

  • Sham comparator
    Sham acupuncture

    Single acupuncture needles will be placed bilaterally onto a sham location in the ear for a duration of 20 minutes.

    Procedure: Epidural injection

  • Placebo comparator
    Simulated acupuncture

    Acupuncture will be simulated with a paper clip.

    Procedure: Epidural injection

Interventions

  • DeviceShen Men acupuncture

    20-minute acupuncture session

  • ProcedureEpidural injection

    Epidural injection for the relief of back pain

05

What researchers measure

Primary outcomes

  1. Anxiety

    Change in anxiety from baseline (pre-acupuncture intervention) will be measured using the State subscale of the State Trait Anxiety Inventory (STAI). The STAI is a psychological inventory based on a 4-point Likert scale and consists of 40 questions on a self-report basis. The STAI is one of the first tests to assess both state and trait anxiety separately. Each type of anxiety has its own scale of 20 different questions that are scored. Scores range from 20 to 80, with higher scores correlating with greater anxiety. Low scores indicate a mild form of anxiety whereas median scores indicate a moderate form of anxiety and high scores indicate a severe form of anxiety. The 4-point scale for S-anxiety is as follows: 1.) not at all, 2.) somewhat, 3.) moderately so, 4.) very much so. The 4-point scale for T-anxiety is as follows: 1.) almost never, 2.) sometimes, 3.) often, 4.) almost always.

    Time frame: Up to 30 min post-acupuncture intervention

Secondary outcomes

  1. Belief of Acupuncture

    Patients will be asked "On a scale of 0-10, how much do you believe acupuncture to be a valid treatment for anxiety?" (0=do not believe at all; 10=fully believe)

    Time frame: Up to 30 min post-acupuncture intervention

  2. Anxiety Medication Use

    Any use of medication use following the acupuncture intervention and before the epidural injection will be documented.

    Time frame: Up to 30 min post-acupuncture intervention.

06

Results

Posted Oct 1, 2019

Participant flow

Participant flow — Overall Study
MilestoneShen Men AcupunctureSham AcupunctureSimulated Acupuncture
Started121
Completed121
Not completed000

Outcome measures

PrimaryAnxiety

Change in anxiety from baseline (pre-acupuncture intervention) will be measured using the State subscale of the State Trait Anxiety Inventory (STAI). The STAI is a psychological inventory based on a 4-point Likert scale and consists of 40 questions on a self-report basis. The STAI is one of the first tests to assess both state and trait anxiety separately. Each type of anxiety has its own scale of 20 different questions that are scored. Scores range from 20 to 80, with higher scores correlating with greater anxiety. Low scores indicate a mild form of anxiety whereas median scores indicate a moderate form of anxiety and high scores indicate a severe form of anxiety. The 4-point scale for S-anxiety is as follows: 1.) not at all, 2.) somewhat, 3.) moderately so, 4.) very much so. The 4-point scale for T-anxiety is as follows: 1.) almost never, 2.) sometimes, 3.) often, 4.) almost always.

Time frame:
Up to 30 min post-acupuncture intervention
Reported as:
Mean · score on a scale
Anxiety
score on a scaleShen Men AcupunctureSham AcupunctureSimulated Acupuncture
Anxiety0 ± 00.2 ± 4.5-6 ± 0
SecondaryBelief of Acupuncture

Patients will be asked "On a scale of 0-10, how much do you believe acupuncture to be a valid treatment for anxiety?" (0=do not believe at all; 10=fully believe)

Time frame:
Up to 30 min post-acupuncture intervention
Reported as:
Mean · units on a scale
Belief of Acupuncture
units on a scaleShen Men AcupunctureSham AcupunctureSimulated Acupuncture
Belief of Acupuncture8 ± 08 ± 47 ± 0
SecondaryAnxiety Medication Use

Any use of medication use following the acupuncture intervention and before the epidural injection will be documented.

Time frame:
Up to 30 min post-acupuncture intervention.
Reported as:
Count of participants · Participants
Anxiety Medication Use
ParticipantsShen Men AcupunctureSham AcupunctureSimulated Acupuncture
Anxiety Medication Use000

Adverse events

Collected over Adverse event data were collected during the duration of the acupuncture intervention (20 minutes).. Non-serious events are listed at a 0% frequency threshold.

Adverse event summary by group
GroupDeathsSeriousOther
Shen Men Acupuncture0/1 (0%)0/1 (0%)0/1 (0%)
Sham Acupuncture0/2 (0%)0/2 (0%)0/2 (0%)
Simulated Acupuncture0/1 (0%)0/1 (0%)0/1 (0%)

Baseline characteristics

Age, Categorical
Age, Categorical(Participants)Shen Men AcupunctureSham AcupunctureSimulated AcupunctureTotal
<=18 years0000
Between 18 and 65 years1001
>=65 years0213
Age, Continuous
Age, Continuous(years)Shen Men AcupunctureSham AcupunctureSimulated AcupunctureTotal
Mean36 ± 065 ± 087 ± 063 ± 21
Sex: Female, Male
Sex: Female, Male(Participants)Shen Men AcupunctureSham AcupunctureSimulated AcupunctureTotal
Female0213
Male1001
Ethnicity (NIH/OMB)
Ethnicity (NIH/OMB)(Participants)Shen Men AcupunctureSham AcupunctureSimulated AcupunctureTotal
Hispanic or Latino0101
Not Hispanic or Latino1113
Unknown or Not Reported0000
Region of Enrollment
Region of Enrollment(participants)Shen Men AcupunctureSham AcupunctureSimulated AcupunctureTotal
United States1214
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Study locations

1 site
  • Hospital for Special Surgery
    New York, New York 10021, United States
08

References and documents

Study documents

  • Protocol and statistical analysis plan · Mar 7, 2018

Documents are hosted by the registry — open the source record to download them.

09

Registry details

Key details

Study ID
NCT03480919
Lead sponsor
Hospital for Special Surgery, New York
Responsible party
Sponsor
First posted
Mar 29, 2018
Start date
Mar 20, 2018
Primary completion
Jul 31, 2018
Completion
Jul 31, 2018
Results posted
Oct 1, 2019
Last update
Nov 12, 2019

Oversight

FDA-regulated drug
No
FDA-regulated device
Yes
View the source record on ClinicalTrials.gov ↗

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