An interventional study of Sevoflurane Volatile Liquid and Bupivacaine / SUFentanil in Knee Surgery With Tourniquet, sponsored by University of Liege. Completed. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-03-26.
Sponsored by University of Liege · Not applicable, Interventional, and Screening
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia This activation was assessed by plasma myeloperoxidase and elastase measurements in four consecutive blood samples during and after surgery (before surgical incision and 1, 3, 24 hours following tourniquet release.
University of Liege is the lead sponsor of 251 studies on the registry; 50 are open to participants now.
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The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Knee surgery under spinal anesthesia Intervention involves spinal administration of 12,5 mg bupivacaine and 2,5 microgram sufentanil.
Drug: Bupivacaine / SUFentanil
Knee surgery under sevoflurane anesthesia Intervention involves administration of inhaled sevoflurane for maintenance of general anesthesia
Drug: Sevoflurane Volatile Liquid
Drug pages: Bupivacaine · Sufentanil
Changes in plasmatic concentration of myeloperoxidase and elastase
Biological measurement of changes in plasmatic concentration of myeloperoxidase and elastase from preoperative values to one hour after tourniquet release.
Time frame: Before surgical incision and one hour after tourniquet release
Changes in plasmatic concentration of myeloperoxidase and elastase
Biological measurement of changes in plasmatic concentration of myeloperoxidase and elastase from preoperative values to 3 and 24 hours after tourniquet release.
Time frame: Before surgical incision then 3 and 24 hours after tourniquet release
Changes in plasmatic concentration of endothelial biomarkers
Biological measurement of changes in plasmatic concentration of syndecan-1, soluble thrombomodulin, soluble E-selectin and VEGF from preoperative values to one hour after tourniquet release.
Time frame: Before surgical incision and one hour after tourniquet release
Changes in plasmatic concentration of endothelial biomarkers
Biological measurement of changes in plasmatic concentration of syndecan-1, soluble thrombomodulin, soluble E-selectin and VEGF from preoperative values to 3 and 24 hours after tourniquet release.
Time frame: Before surgical incision then 3 and 24 hours after tourniquet release
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Plan to share: No
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Ran from Jan 2016 to primary completion in Mar 2018, 26 months.
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This study is completed, as verified in Mar 2020. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Bupivacaine · Sufentanil