An interventional study of THRIVE and Endotracheal intubation in Anesthesia, sponsored by Karolinska University Hospital. Completed at 1 site in Sweden. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2020-10-14.
Sponsored by Karolinska University Hospital · Not applicable, Interventional, and Treatment
Oxygenation with high-flow nasal cannula with 100% oxygen have now been evaluated in a number of studies and the data are convincing. The THRIVE technique is able to oxygenate patients safely and vital parameters has been shown to be stable. But it is of great importance to evaluate this new concept regarding other potential negative physiological aspects such as lung atelectasis and inflammatory stress response before implementing it into clinical practice.
Exclusion Criteria:
The patients will be intubated and ventilated
Device: Endotracheal intubation
The patients will be oxygenated during apnea using THRIVE
Device: THRIVE
Oxygenation during apnea using transversal humidified oxygen
Ventilation during the procedure is governed by an endotracheal tube in the trachea and mechanical ventilation
Electrical impedans tomography
Changes in lung volumes
Time frame: baseline, intraoperative, 2 hours after start of intervention
Difference in Endtidal and arterial carbon dioxide partial pressure in the end of the procedure
Difference in Endtidal and arterial carbon dioxide partial pressure in the end of the procedure
Time frame: max 30 minutes after start of intervention
Increase in arterial carbon dioxide during the apnea
Measurement of arterial blood gases and here arterial carbon dioxide
Time frame: max 30 minutes after start of intervention
Plan to share: Undecided
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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Karolinska University Hospital