An observational study in Endometrial Receptivity, sponsored by Instituto Valenciano de Infertilidad, IVI VALENCIA. Completed at 1 site in Spain. Open to female participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2019-04-03.
Sponsored by Instituto Valenciano de Infertilidad, IVI VALENCIA · Observational
Since the implantation is related with endometrial receptivity, the patient specific plasma progesterone concentration influences this pattern.
Following this hypothesis, the study establishes a correlation between the serum progesterone measured on the day of the endometrial biopsy and the endometrial receptivity with the ERA test.
In patients who have had problems of assisted reproduction it is essential to establish the factors that contribute to the success of a cycle: correcting these factors means increasing the possibility of the cycle culminating in pregnancy.
In patients with embryonic implantation failures, a prevalence of non-receptive endometrium has been described after performing the ERA test of around 20%. On the other hand, a study that shows embryonic generation values below a certain threshold (25th percentile), presents a rate of evolutionary clinical gestation and lower embryo implantation.
It is logical to think that progesterone levels are lower than the state of endometrial receptivity, since the hormone is responsible for the endothelial changes that prepare the uterus for implantation. It is ERA. The result of this study is the result of the evaluation of the lifetime of the endometrial biopsy is related to the result of the same.
If desired, the determination of the probability of the day of the transfer is predictive of the pregnancy rate through the impact that the hormone has on the endometrial receptivity. This would allow to decide in the same cycle, if the patient should be in a transfer to another dimension, or should it defer to another cycle where obtain the optimal values of progesterone.
Nowadays, there are no publications in the literature that have related the concentration of progesterone with endometrial receptivity through ERA. This is the first prospective study that analyzes this relationship.
The ERA test has been chosen for the evaluation of endometrial receptivity, which is a tool that has been widely used and used in the usual clinical practice of our clinic.
Infertile patients with background of failed IVF cycles in which an endometrial receptivity test (ERA test) is performed in the context of an artificial cycle.
Exclusion Criteria:
Progesterone plasma levels and Endometrial receptivity analysis result
To evaluate correlation between progesterone plasma levels and endometrial receptivity through ERA test in infertile women.
Time frame: 7 months
Relationship between progesterone levels in uterus and in plasma
To evaluate correlation between progesterone uterine levels and progesterone plasma levels
Time frame: 8 months
Relationship between progesterone uterine levels and Endometrial receptivity
To evaluate correlation between progesterone uterine levels and endometrial receptivity through ERA test.
Time frame: 8 months
This study is completed, as verified in Apr 2019. You cannot join it, but the record below documents what was studied.
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Instituto Valenciano de Infertilidad, IVI VALENCIA